Direct synthesis of water dispersible superparamagnetic TGA capped FePt nanoparticles: One pot, one shot

Jha, Deepak Kumar; Varadarajan, Komanduri S.; Patel, Anant B.; Deb, Pritam

doi:10.1016/j.matchemphys.2015.03.016

Cited by 7 publications

(2 citation statements)

References 19 publications

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“…in magnetothermic heating or imaging techniques, such as Magnetic Resonance Imaging (MRI). 32,33,37 With respect to this, sub-10 nm FePt NPs turn out to be very promising for such applications, as they exhibit high magnetic moments up to 1000 emu/cc and high chemical stability and they can be synthesized with well-defined size, narrow size distribution and after synthesis they adapt the disordered fcc structure. [19][20][21] However, FePt NPs need to be stabilized with oleic acid and oleyl amine and are therefore hydrophobic.…”

Section: Introductionmentioning

confidence: 99%

“…by ligand exchange reaction, or by direct synthesis. 23,24,37 For water soluble FePt NPs, however, concerns arose about the possible cytotoxicity due to the leaching of Pt ions, which hinders applications in vivo or possible cytotoxic properties are not yet studied. 25 Another method to transfer FePt NPs in the aqueous phase was demonstrated by introducing a silica shell surrounding the FePt core.…”

Section: Introductionmentioning

confidence: 99%

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Hydrophobic superparamagnetic FePt nanoparticles in hydrophilic poly(N-vinylcaprolactam) microgels: a new multifunctional hybrid system

et al. 2017

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We report the synthesis of a new multifunctional colloidal hybrid system consisting of thermoresponsive amphiphilic biocompatible poly(N-vinylcaprolactam) microgels loaded with hydrophobic superparamagnetic FePt nanoparticles (NPs). In a first step water swellable poly(N-vinylcaprolactam) microgels were mixed with hydrophobicly coated sub-10 nm, superparamagnetic FePt NPs in a tetrahydrofurane (THF) solution. In a second step, changing the surrounding solvent from THF to water forces the FePt NPs to migrate into the amphiphilic microgels. The new hybrid colloids (i) are colloidally stable in water and the thermo-responsive properties in terms of a volume phase transition is retained, (ii) exhibit superparamagnetic characteristics introduced by FePt NPs, (iii) show a drastically reduced cytotoxicity compared to water soluble FePt NP of similar size, as known from literature. This makes the new hybrid microgels suited e.g. as biocompatible containers for drug delivery or for imaging.

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