Direct transcutaneous electroneurostimulation in the treatment of pathologies of the peripheral nervous system

Al-Zamil, Mustafa; Kulikova, Natalia; Миненко, И. А.; Vasilieva, E.S.

doi:10.33920/med-14-2006-07

Cited by 7 publications

(5 citation statements)

References 37 publications

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“…Secondly, improvements in damaged peripheral nerve condition with decreased nociceptive afferentation and increased sensory afferentation. In the best-case scenario, this mechanism prevents the development of central sensitization or, in the least, slows down the process of its formation [ 10 , 11 , 13 , 37 ].…”

Section: Discussionmentioning

confidence: 99%

“…Peroneal and tibial nerves were stimulated for 5 min each ( Figure 2 ). There was a total of 15 sessions carried out on alternate days [ 1 , 10 , 11 ].…”

Section: Methodsmentioning

confidence: 99%

“…Previous studies demonstrated that direct TENS enhances the efficacy of standard drug therapy in the treatment of diabetic distal neuropathy by reducing negative sensory dysfunction by 1.5 times, positive sensory dysfunction by 2.1 times and neuropathic pain in 40% [ 1 , 10 , 11 ].…”

Section: Introductionmentioning

confidence: 99%

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Clinical Experience of High Frequency and Low Frequency TENS in Treatment of Diabetic Neuropathic Pain in Russia

et al. 2022

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Background: Transcutaneous electrical nerve stimulation (TENS) is presently one of the main methods of treatment for neuropathic pain in type II diabetes mellitus. The discussion about which TENS frequency is more effective in the treatment of neuropathic pain has been ongoing for many years. Despite this, the response of different aspects of neuropathic pain to various TENS modalities has not been sufficiently studied. Aim: To analyze changes in characteristics of neuropathic pain depending on the frequency of TENS. Materials and methods: Seventy-five Russian diabetic patients with painful distal axonal neuropathy were enrolled in the study. Patients were assigned to three groups: in the HF TENS group, 25 patients received standard drug therapy (Alpha-lipoic acid, Pentoxifylline, Vitamin B12, Gabapentin) + high-frequency TENS (HF); in the LF TENS group, 25 patients received standard drug therapy (Alpha-lipoic acid, Pentoxifylline, Vitamin B12, Gabapentin) + low-frequency TENS (LF); in the control group, 25 patients underwent just standard drug therapy (Alpha-lipoic acid, Pentoxifylline, Vitamin B12, Gabapentin). Pain intensity was calculated before and after treatment with visual analogue scale (VAS), McGill pain questionnaire (MPQ), Douleur Neuropathique 4 Questions (DN4) and Pain Drawing. Results: TENS increased the therapeutic effect of standard drug therapy, in the treatment of neuropathic pain, by 65.9% and prolonged its efficacy by 31% for up to 6 months after treatment. HF TENS had a more pronounced analgesic effect than LF TENS based on VAS (34.7%), sensory (57.6%) MPQ dimensions and DN4 (21%). Affective MPQ dimension with the use of LF TENS was lower than HF TENS by 34.7% immediately after treatment, by 47.3% after 2 months and by 34.8% after 6 months of the follow-up period. Conclusion: There are significant differences between HF and LF TENS based on pain assessment using various pain scales. This reflects the distinctive effects of different TENS modalities on different aspects of neuropathic pain.

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Section: Discussionmentioning

confidence: 99%

“…Peroneal and tibial nerves were stimulated for 5 min each ( Figure 2 ). There was a total of 15 sessions carried out on alternate days [ 1 , 10 , 11 ].…”

Section: Methodsmentioning

confidence: 99%

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Clinical Experience of High Frequency and Low Frequency TENS in Treatment of Diabetic Neuropathic Pain in Russia

et al. 2022

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“…Following TENS, there was a decrease in BOLD signal in limbic brain regions, including the amygdala, hippocampus, parahippocampal gyrus, middle, and superior temporal gyrus, which was accompanied by increased activation of the insula, precentral gyrus, and thalamus [ 75 , 76 ]. The anxiolytic effect of TENS has been found in the treatment of patients with insomnia [ 77 , 78 ], distal polyneuropathy [ 27 ], carpal tunnel syndrome [ 26 ], post-traumatic stress disorder [ 79 ], post-hemorrhoidectomy syndrome [ 80 ], in preoperative anxiolytic preparation before thoracoscopic surgery [ 81 ], during induction of labor [ 44 ], and dental procedures [ 82 ]. However, in rare studies, TENS has been successfully used in the treatment of GAD [ 29 ].…”

Section: Discussionmentioning

confidence: 99%

“…Anatomically, this point is located above the median nerve in the carpal tunnel [ 84 ]. Electrical stimulation of these acupuncture points improves functional connections between brain regions associated with normalizing emotions by 24.9% [ 78 , 85 , 86 ]. The anxiolytic effect results from activation of the prefrontal cortex, insula, temporal gyrus, anterior cingulate cortex, temporal pole, dorsolateral prefrontal cortex, and inferior frontal cortex, which are closely associated with cognition, spirit, and emotion in the brain [ 86 ].…”

Section: Discussionmentioning

confidence: 99%

Comparative Analysis of High-Frequency and Low-Frequency Transcutaneous Electrical Stimulation of the Right Median Nerve in the Regression of Clinical and Neurophysiological Manifestations of Generalized Anxiety Disorder

Al-Zamil,

Kulikova,

Minenko

et al. 2024

JCM

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Background/Objectives: The anxiolytic effect of transcutaneous electrical nerve stimulation (TENS) is associated with the activation of endogenous inhibitory mechanisms in the central nervous system. Both low-frequency, high-amplitude TENS (LF-TENS) and high-frequency, low-amplitude TENS (HF-TENS) are capable of activating opioid, GABA, serotonin, muscarinic, and cannabinoid receptors. However, there has been no comparative analysis of the effectiveness of HF-TENS and LF-TENS in the treatment of GAD. The purpose of our research was to study the effectiveness of direct HF-TENS and LF-TENS of the right median nerve in the treatment of patients with GAD compared with sham TENS. Methods: The effectiveness of direct HF-TENS and LF-TENS of the right median nerve in the treatment of GAD was studied using Generalized Anxiety Disorder 7-item scale (GAD-7) and the Hamilton Anxiety Rating Scale (HAM-A). 40 patients underwent sham TENS, 40 patients passed HF-TENS (50 Hz—50 μs—sensory response) and 41 patients completed LF –TENS (1 Hz—200 μs—motor response) for 30 days daily. After completion of treatment, half of the patients received weekly maintenance therapy for 6 months. Electroencephalography was performed before and after treatment. Results: Our study showed that a significant reduction in the clinical symptoms of GAD as assessed by GAD-7 and HAM-A was observed after HF-TENS and LF-TENS by an average of 42.4%, and after sham stimulation only by 13.5% for at least 2 months after the end of treatment. However, LF-TENS turned out to be superior in effectiveness to HF-TENS by 51% and only on electroencephalography leads to an increase in PSD for the alpha rhythm in the occipital regions by 24% and a decrease in PSD for the beta I rhythm in the temporal and frontal regions by 28%. The prolonged effect of HF-TENS and LF-TENS was maintained without negative dynamics when TENS treatment was continued weekly throughout the entire six-month observation period. Conclusions: A prolonged anxiolytic effect of direct TENS of the right median nerve has been proven with greater regression of clinical and neurophysiological manifestations of GAD after LF-TENS compared to HF-TENS. Minimal side effects, low cost, safety, and simplicity of TENS procedures are appropriate as a home treatment modality.

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Comparative analysis of labile and stable high-frequency TENS in the treatment of neuropathic pain syndrome

Al-Zamil

2021

Fizioterapevt (Physiotherapist)

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Introduction: There have been many works devoted to the comparative analysis of high-frequency and low-frequency TENS in the treatment of neuropathic pain syndrome. Meanwhile, the comparative analysis of the methods of labile and stable TENS has not been sufficiently studied to date. Purpose: To make a comparative analysis of labile and stable high-frequency TENS in the treatment of neuropathic pain syndrome in patients with distal polyneuropathy of the lower extremities (DPLE). Materials and methods: 64 patients (F: 34, M: 30) with severe neuropathic pain syndrome on the background of diabetic DPLE were studied. Depending on the method of high-frequency TENS, all patients were divided into 2groups: stable high-frequency TENS (n=31) and labile high-frequency TENS (n=33). TENS was carried out every other day for a month. The severity of pain was determined by the VAS before each procedure. Results: The reduction of pain syndrome with the use of labile stimulation was 76.9%, compared to stable stimulation — 41,6%. With daily registration of pain syndrome, a significant increase in pain syndrome was revealed in patients who underwent stable high-frequency TENS after the 7th procedure to 4,5±0,3points in comparison with the indicators of pain syndrome obtained after the 3rd procedure (3,2±0,14). Conclusions: The analgesic effect of the labile high-frequency TENS significantly exceeds the analgesic effect of the stable high-frequency TENS by 85.1%. Partial tolerance to high-frequency TENS is observed when applying stable stimulation, which develops after the 7th procedure and is not observed after labile TENS.

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Direct transcutaneous electroneurostimulation in the treatment of pathologies of the peripheral nervous system

Cited by 7 publications

References 37 publications

Clinical Experience of High Frequency and Low Frequency TENS in Treatment of Diabetic Neuropathic Pain in Russia

Clinical Experience of High Frequency and Low Frequency TENS in Treatment of Diabetic Neuropathic Pain in Russia

Comparative Analysis of High-Frequency and Low-Frequency Transcutaneous Electrical Stimulation of the Right Median Nerve in the Regression of Clinical and Neurophysiological Manifestations of Generalized Anxiety Disorder

Comparative analysis of labile and stable high-frequency TENS in the treatment of neuropathic pain syndrome

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