1991
DOI: 10.1097/00000441-199105000-00002
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Direct Vasodilator Effect of Hyperventilation-Induced Hypocarbia in Autonomic Failure Patients

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Cited by 41 publications
(37 citation statements)
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“…In addition, baseline mean ABP in patients increased significantly during hypercapnia. This is in line with the study of Onrot et al, who have shown a similar increase in ABP during breathing of 5 % CO 2 in patients with autonomic failure [36]. In a previous study, however, we were not able to demonstrate a significant sympathomimetic effect of hypercapnia in patients with autonomic failure [37].…”
Section: Discussionsupporting
confidence: 93%
“…In addition, baseline mean ABP in patients increased significantly during hypercapnia. This is in line with the study of Onrot et al, who have shown a similar increase in ABP during breathing of 5 % CO 2 in patients with autonomic failure [36]. In a previous study, however, we were not able to demonstrate a significant sympathomimetic effect of hypercapnia in patients with autonomic failure [37].…”
Section: Discussionsupporting
confidence: 93%
“…This has been reported in patients with autonomic failure. 21 The sinus arrhythmia ratio in response to controlled breathing was blunted in our subjects (1.05Ϯ0.01; normal, Ͼ1.2).…”
Section: Patient Characterizationmentioning
confidence: 57%
“…9,17,18 Thus, modest increases in arterial carbon dioxide concentration elicit an increase in BP, while decreases in carbon dioxide concentration are associated with decreases in BP. 19 A hyperventilation-induced decrease in BP could conceivably decrease cerebral perfusion pressure in autonomic failure patients.…”
Section: Discussionmentioning
confidence: 99%