Direct-Writing of Cu Nano-Patterns with an Electron Beam

Lai, Shih-En; Hong, Ying-Jhan; Chen, Yuting; Kang, Yu-Ting; Chang, Po‐Cheng; Yew, Tri‐Rung

doi:10.1017/s1431927615015111

Cited by 4 publications

(6 citation statements)

References 23 publications

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“…Specimens in aqueous solution can be loaded into the chamber and then examined by an electron microscope. Previously, images of non-biological particles and living bacteria were successfully demonstrated with this microchip [3][4][5]. Sample preparation steps of this microchip are simpler and faster than those of traditional TEM.…”

Section: Introductionmentioning

confidence: 99%

A Novel Microchip Technique for Quickly Identifying Nanogranules in an Aqueous Solution by Transmission Electron Microscopy: Imaging of Platelet Granules

et al. 2020

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Ultrastructural observation of biological specimens or nanogranules usually requires the use of electron microscopy. Electron microscopy takes a lot of time, requires many steps, and uses many chemicals, which may affect the native state of biological specimens. A novel microchip (K-kit) was used as a specimen kit for in situ imaging of human platelet granules in an aqueous solution using a transmission electron microscope. This microchip enabled us to observe the native human platelet granules very quickly and easily. The protocols included blood collection, platelet purification, platelet granule isolation, sample loading into this microchip, and then observation by a transmission electron microscope. In addition, these granules could still remain in aqueous solution, and only a very small amount of the sample was required for observation and analysis. We used this microchip to identify the native platelet granules by negative staining. Furthermore, we used this microchip to perform immunoelectron microscopy and successfully label α-granules of platelets with the anti-P-selectin antibody. These results demonstrate that the novel microchip can provide researchers with faster and better choices when using a transmission electron microscope to examine nanogranules of biological specimens in aqueous conditions.

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Section: Introductionmentioning

confidence: 99%

A Novel Microchip Technique for Quickly Identifying Nanogranules in an Aqueous Solution by Transmission Electron Microscopy: Imaging of Platelet Granules

et al. 2020

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“…Thus, the layer thickness was not sensitive to the surfactant concentration either. Moreover, in our previous investigations, the LB solution 22 (1 wt% tryptone, 0.5 wt% sodium chloride, and 0.5 wt% yeast extract in DI water) and the 24 mM CuSO 4 solution 23 yielded water layer thicknesses of approximately 180 nm and 200 nm, respectively. These results provide evidence for the water layer thickness being independent of PS beads and its surfactant.…”

Section: Resultsmentioning

confidence: 83%

Stable water layers on solid surfaces

Hong

Tai²,

Chen³

et al. 2016

Phys. Chem. Chem. Phys.

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Liquid layers adhered to solid surfaces and that are in equilibrium with the vapor phase are common in printing, coating, and washing processes as well as in alveoli in lungs and in stomata in leaves. For such a liquid layer in equilibrium with the vapor it faces, it has been generally believed that, aside from liquid lumps, only a very thin layer of the liquid, i.e., with a thickness of only a few nanometers, is held onto the surface of the solid, and that this adhesion is due to van der Waals forces. A similar layer of water can remain on the surface of a wall of a microchannel after evaporation of bulk water creates a void in the channel, but the thickness of such a water layer has not yet been well characterized. Herein we showed such a water layer adhered to a microchannel wall to be 100 to 170 nm thick and stable against surface tension. The water layer thickness was measured using electron energy loss spectroscopy (EELS), and the water layer structure was characterized by using a quantitative nanoparticle counting technique. This thickness was found for channel gap heights ranging from 1 to 5 μm. Once formed, the water layers in the microchannel, when sealed, were stable for at least one week without any special care. Our results indicate that the water layer forms naturally and is closely associated only with the surface to which it adheres. Our study of naturally formed, stable water layers may shed light on topics from gas exchange in alveoli in biology to the post-wet-process control in the semiconductor industry. We anticipate our report to be a starting point for more detailed research and understanding of the microfluidics, mechanisms and applications of gas-liquid-solid systems.

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“… Medium High versatility, Ordered morphology, Medium controllability. [57] , [58] , [59] , [60] Anodization Metals Nanopores, Nanotubes. Very low (mostly TiO 2 ) Low versatility, Random or ordered morphologies, Medium controllability.…”

Section: Nanostructured Surfaces For Cardiovascular Applicationsmentioning

confidence: 99%

“…In addition, Lai et al. [60] used electron beam to obtain 70–280 nm Cu nanowires. The electron beam induced the Cu deposition on the surface of the substrate.…”

Section: Nanostructured Surfaces For Cardiovascular Applicationsmentioning

confidence: 99%

“…Lai et al. [60] used electron beam to induce the reduction of Cu 2+ into Cu solid in the solution of CuSO 4 , which produced Cu nanowires. The design of chemical or physical process that results in final solid nanostructures should be taken into thorough consideration to achieve a successful direct writing fabrication.…”

Section: Nanostructured Surfaces For Cardiovascular Applicationsmentioning

confidence: 99%

See 1 more Smart Citation

Nanomaterials for treating cardiovascular diseases: A review

Jiang

Rutherford

Vuong

et al. 2017

Bioactive Materials

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Nanomaterials such as nanostructured surfaces, nanoparticles, and nanocomposites represent new viable sources for future therapeutics for cardiovascular diseases. The special properties of nanomaterials such as their intrinsic physiochemical properties, surface energy and surface topographies could actively enhance desirable cellular responses within the cardiovascular system, projecting a growing potential for clinical translation. Recent progress on nanomaterials opened up new opportunities for treating cardiovascular diseases. Successful translation of nanomaterials into cardiovascular applications requires a comprehensive understanding of both nanomaterials and biomedicine, and, thus, it is critical to stress current advancements on both sides. In this review, the authors introduced crucial fabrication techniques for promising nanomaterials for cardiovascular applications. This review highlighted the key elements to consider for their fabrication, properties and applications. The important concerns relevant to cardiovascular nanomaterials, such as cellular responses to nanomaterials and the toxicity of nanomaterials, are also discussed. This review provided an overview of necessary knowledge and key concerns on nanomaterials specific for treating cardiovascular diseases, from the perspectives of both material science and biomedicine.

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Direct-Writing of Cu Nano-Patterns with an Electron Beam

Cited by 4 publications

References 23 publications

A Novel Microchip Technique for Quickly Identifying Nanogranules in an Aqueous Solution by Transmission Electron Microscopy: Imaging of Platelet Granules

A Novel Microchip Technique for Quickly Identifying Nanogranules in an Aqueous Solution by Transmission Electron Microscopy: Imaging of Platelet Granules

Stable water layers on solid surfaces

Nanomaterials for treating cardiovascular diseases: A review

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