Directed Assembly of Sub‐Nanometer Thin Organic Materials with Programmed‐Size Nanopores

Danila, Delia; Banner, L. Todd; Karimova, Evguenia J.; Tsurkan, Lyudmila; Wang, Xinyan; Pinkhassik, Eugene

doi:10.1002/anie.200801814

Cited by 51 publications

(85 citation statements)

References 33 publications

(12 reference statements)

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“…3,4,6 As we have previously shown, hydrophobic molecules, such as glucose pentaesters, can be dissolved in the bilayer interior together with monomers (Figure 8). …”

Section: Resultsmentioning

confidence: 72%

Scattering Studies of Hydrophobic Monomers in Liposomal Bilayers: An Expanding Shell Model of Monomer Distribution

et al. 2011

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Hydrophobic monomers partially phase-separate from saturated lipids when loaded into lipid bilayers in amounts exceeding 1:1 monomer:lipid molar ratio. This conclusion is based on agreement between two independent methods of examining the structure of monomer-loaded bilayers. Complete phase separation of monomers from lipids would result in increase in bilayer thickness and slight increase in the diameter of liposomes. Homogeneous distribution of monomers within the bilayer would not change the bilayer thickness and would lead to the increase in the liposome diameter. The increase in bilayer thickness, measured by the combination of small angle neutron scattering (SANS) and small angle X-ray scattering (SAXS), was approximately one half of what was predicted for complete phase separation. The increase in liposome diameter, measured by dynamic light scattering (DLS), was in the middle between values predicted for homogeneous distribution and complete phase separation. Combined SANS, SAXS, and DLS data suggest that at 1.2 monomer:lipid ratio, approximately one half of monomers are located in an interstitial layer sandwiched between lipid sheets. These results expand our understanding of using self-assembled bilayers as scaffolds for directed covalent assembly of organic nanomaterials. In particular, partial phase separation of monomers from lipids corroborates successful creation of nanometer-thin polymer materials with uniform imprinted nanopores. Pore-forming templates do not need to span the lipid bilayer to create a pore in the bilayer-templated films.

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“…3,4,6 As we have previously shown, hydrophobic molecules, such as glucose pentaesters, can be dissolved in the bilayer interior together with monomers (Figure 8). …”

Section: Resultsmentioning

confidence: 72%

Scattering Studies of Hydrophobic Monomers in Liposomal Bilayers: An Expanding Shell Model of Monomer Distribution

et al. 2011

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“…24, 25, 27 Monomers were loaded into the lipid bilayer during the preparation of liposomes. Liposomes were prepared by hydration of lipid/monomer mixture with the aqueous solution of ICG.…”

Section: Resultsmentioning

confidence: 99%

Blood triggered rapid release porous nanocapsules

et al. 2013

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Rapid-release drug delivery systems present a new paradigm in emergency care treatments. Such systems combine a long shelf life with the ability to provide a significant dose of the drug to the bloodstream in the shortest period of time. Until now, development of delivery formulations has concentrated on slow release systems to ensure a steady concentration of the drug. To address the need for quick release system, we created hollow polyacrylate nanocapsules with nanometer-thin porous walls. Burst release occurs upon interaction with blood components that leads to escape of the cargo. The likely mechanism of release involves a conformational change of the polymer shell caused by binding albumin. To demonstrate this concept, a near-infrared fluorescent dye indocyanine green (ICG) was incorporated inside the nanocapsules. ICG-loaded nanocapsules demonstrated remarkable shelf life in aqueous buffers with no release of ICG for twelve months. Rapid release of the dye was demonstrated first in vitro using albumin solution and serum. SEM and light scattering analysis demonstrated the retention of the nanocapsule architecture after the release of the dye upon contact with albumin. In vivo studies using fluorescence lifetime imaging confirmed quick discharge of ICG from the nanocapsules following intravenous injection.

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“…Synthesis of glucose tetraacetate coupled with 4-vinylbenzoic acid5 and Reactive Blue dye coupled with β–cyclodextrin4 was described previously. All other chemicals and Sephadex G-50 were purchased from Sigma-Aldrich.…”

Section: Methodsmentioning

confidence: 99%

Synthesis, Characterization, and Long-Term Stability of Hollow Polymer Nanocapsules with Nanometer-Thin Walls

et al. 2010

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Hollow polymer nanocapsules are produced by the polymerization within hydrophobic interior of lipid bilayers that act as temporary self-assembled scaffolds. Pore-forming templates are codissolved with monomers in the bilayers to create pores with controlled size and chemical environment. Polymerization was monitored with UV spectroscopy and dynamic light scattering. High resolution magic angle spinning NMR characterization provided detailed structural information about nanocapsules. Spherical shape was confirmed by electron microscopy. Mediumsized molecules can be entrapped within porous nanocapsules. No release of encapsulated molecules was observed within 240 days.

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Directed Assembly of Sub‐Nanometer Thin Organic Materials with Programmed‐Size Nanopores

Cited by 51 publications

References 33 publications

Scattering Studies of Hydrophobic Monomers in Liposomal Bilayers: An Expanding Shell Model of Monomer Distribution

Scattering Studies of Hydrophobic Monomers in Liposomal Bilayers: An Expanding Shell Model of Monomer Distribution

Blood triggered rapid release porous nanocapsules

Synthesis, Characterization, and Long-Term Stability of Hollow Polymer Nanocapsules with Nanometer-Thin Walls

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