Directed evolution of C-methyltransferase PsmD for enantioselective pyrroloindole derivative production
Diana A. Amariei,
Julia Tenhaef,
Thomas Classen
et al.
Abstract:The engineering of stereoselective C-methyltransferase PsmD through saturation mutagenesis led to improved activity for larger substrates. An automated process was designed and successfully applied for the mutant library production and screening.
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