Directing filtration to narrow molecular weight distribution of oligodextran in an enzymatic membrane reactor

Su, Ziran; Luo, Jianquan; Pinelo, Manuel; Wang, Yujue

doi:10.1016/j.memsci.2018.03.062

Cited by 40 publications

(29 citation statements)

References 43 publications

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“…Su et al. reported that the prefiltration of dextranase to form a fouling layer on the UF membrane could not only stabilize the enzyme but also narrow the membrane pore size distribution, thus, leading to a higher uniformity of oligodextran products [43]. Inspired by this work, it is noted that during the preparation of biocatalytic membranes for biomolecule production, the effect of enzyme immobilization on membrane pore size and separation selectivity needs to be considered.…”

Section: Applications Of Biocatalytic Membranementioning

confidence: 98%

“…Since the pore size distribution of the commercially available membranes is uneven, it is not easy to get high‐quality product with narrow molecular weight distribution. As mentioned in Section 3.4, enzyme immobilization can also be used for regulation of membrane pore size and its distribution, improving the product molecular weight distribution [43].…”

Section: Key Challenges Faced By Biocatalytic Membranementioning

confidence: 99%

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Biocatalytic membrane: Go far beyond enzyme immobilization

Luo

Song

Zhang

et al. 2020

Engineering in Life Sciences

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Biocatalytic membrane takes advantages of reaction–separation integration as well as enzyme immobilization, which has attracted increasing attentions in online detection and biomanufacturing. However, the high preparation cost, inferior comprehensive performance, and low stability limit its applications. Thus, besides enzyme immobilization, more efforts should be made in biocatalytic membrane configuration design for a specific application to enhance the synergistic effect of reaction and separation and improve its operating stability. This review summarized the recent progress on biocatalytic membrane preparation, discussed different membrane configurations for various applications, finally proposed several challenges and possible solutions, which provided directions and guides for the development and industrialization of biocatalytic membrane.

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Section: Applications Of Biocatalytic Membranementioning

confidence: 98%

Section: Key Challenges Faced By Biocatalytic Membranementioning

confidence: 99%

Biocatalytic membrane: Go far beyond enzyme immobilization

Luo

Song

Zhang

et al. 2020

Engineering in Life Sciences

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“…Latin symbols 0.0014 m 2 Average pore size of membrane (R p ) 10 10 nm Membrane porosity (ε μ ) 31 0.8 Membrane tortuosity (τ) 32 1.6 Viscosity of feed solution (μ) 33 3.5×10 -3 Pa•s Density of feed solution (ρ) 33 1050 kg/m 3…”

Section: List Of Symbolsmentioning

confidence: 99%

Mathematical modelling of reaction-separation in an enzymatic membrane reactor during oligodextran production

Chen³

et al. 2020

Preprint

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Process analysis and optimization of an EMR system used for producing oligodextran are critical to improving EMR operating stability and cost effectiveness. We developed a mathematical model to evaluate the effects of operating conditions and membrane properties on the reaction-separation behavior of an EMR. Our analysis shows that tailoring a membrane with large porosity and uniform pore size distribution can simultaneously improve product quality and production efficiency. The optimum parameters of operating pressure and agitation speed depend on the selection of operating mode. A higher operating pressure was preferable for increasing the production efficiency of the EMR system under a water feeding mode. However, since the membrane suffered more severe fouling under a substrate feeding mode, extensive agitation was required to inhibit membrane fouling and enhance production yield. Our work paves the way for a new approach towards design of highly effective and low-consumptive EMR systems for oligodextran productio Hosted file image1.emf available at https://authorea.com/users/331266/articles/457956-mathematicalmodelling-of-reaction-separation-in-an-enzymatic-membrane-reactor-during-oligodextranproduction

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“…For instance, oligosaccharides (e.g., inulin and oligofructose) have been widely studied for their effects similar to dietary fiber . Low molecular weight dextrans (<10 kDa) can be used in the medical field; such compounds have proven to be useful as a blood substitute according to their effect of controlling osmotic pressure, viscosity, and oxygen flow, avoiding the aggregation of erythrocytes …”

Section: Potentialities Of the Recovered Metabolitesmentioning

confidence: 99%

Metabolites recovery from fermentation broths via pressure‐driven membrane processes

Díaz‐Montes

Castro‐Muñoz

2019

Asia-Pacific J Chem Eng

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The production of specific metabolites using microorganism has been promoted and enhanced by two different approaches, such as modification of the metabolic pathways of microorganism and optimization of culture medium conditions to synthesize specific compounds. However, research community is today focused on the development of processes and techniques for a suitable recovery of metabolites from different stages of fermentation. For this purpose, the use of organic solvents has been the most common approach for the recovery of specific target compounds according to the solvent affinity. Additionally, these techniques also require the implementation of unit processes to obtain better recovery rates; it means that solvent extraction methods need the implementation of additional steps to recover the solvents used, which may involve the increase of final costs in the production process. For this reason, researchers have started to consider membrane-based technologies (e.g. microfiltration [MF], ultrafiltration [UF], and nanofiltration [NF]), as an alternative for the recovery of metabolites from fermentation broths. Therefore, the objective of this paper is to provide an overview of the current findings of the recovery of metabolites from fermentation broths by means of pressuredriven membrane processes. Particular attention will be paid to relevant data, analyzing and discussing according to the membrane features, metabolite properties, and some other phenomena that influence in the separation.Moreover, a framework of the application of the MF, UF, and NF processes in solutes recovery is addressed. Finally, some fundamentals of these processes are also given.

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Directing filtration to narrow molecular weight distribution of oligodextran in an enzymatic membrane reactor

Cited by 40 publications

References 43 publications

Biocatalytic membrane: Go far beyond enzyme immobilization

Biocatalytic membrane: Go far beyond enzyme immobilization

Mathematical modelling of reaction-separation in an enzymatic membrane reactor during oligodextran production

Metabolites recovery from fermentation broths via pressure‐driven membrane processes

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