Direction information coordinated via the posterior third of the corpus callosum during bimanual movements

Eliassen, James C.; Baynes, Kathleen; Gazzaniga, Michael S.

doi:10.1007/s002210050884

Cited by 94 publications

(61 citation statements)

References 29 publications

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“…In contrast, control subjects exhibited interference on all of these measures when producing asymmetric shapes. These results indicate that interference based on the spatial characteristics of the movements arises through callosally mediated interactions, consistent with the notion that the spatial goals are established at a cortical level (see also Eliassen et al 1999;Kennerley et al 2002).…”

Section: Introductionsupporting

confidence: 86%

The Role of the Corpus Callosum in the Coupling of Bimanual Isometric Force Pulses

Diedrichsen

Hazeltine

Nurss

et al. 2003

Journal of Neurophysiology

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The role of the corpus callosum in the coupling of bimanual isometric force pulses. J Neurophysiol 90: 2409 -2418, 2003; 10.1152/jn.00250.2003. Two split-brain patients, a patient with callosal agenesis, and 6 age-matched control participants were tested on a bimanual force production task. The participants produced isometric responses with their index fingers, attempting to match the target force specified by a visual stimulus. On unimanual trials, the stimuli were presented in either the left or right visual field and the response was made with the ipsilateral hand. On bimanual trials, two stimuli were presented, one on each side, and the target forces could be either identical or different. Bimanual responses of the control subjects showed strong evidence of coupling. Forces produced by one hand were influenced by the forces produced by the other hand with positive correlations observed for all target force combinations. These assimilation effects and correlations were greatly attenuated in the acallosal group, with similar results observed for the split-brain patients and participant with callosal agenesis. Furthermore, the processes involved in selecting and planning the two responses occurred independently in the acallosal group; in contrast to the controls, the three acallosal participants exhibited no differences in reaction times or accuracy between bimanual trials in which the two target forces were the same or different. We also found a striking temporal desynchronization of the responses in the split-brain patients, indicating that in this context, temporal coupling is impaired after callosotomy. These results are congruent with the hypothesis that interference related to response selection and planning of bimanual force pulses arises from callosal interactions.

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Section: Introductionsupporting

confidence: 86%

The Role of the Corpus Callosum in the Coupling of Bimanual Isometric Force Pulses

Diedrichsen

Hazeltine

Nurss

et al. 2003

Journal of Neurophysiology

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“…This is in disagreement with a previous work showing the importance of posterior corpus callosum in bimanual coordination (Eliassen et al, 2000); however, whereas visual information was used in this experimental paradigm, in our study, subjects performed acoustically paced motor tasks without any visual facilitation. Furthermore, it was found that visual and visuospatial integration is disrupted by posterior callosotomy (Gazzaniga and Freedman, 1973;Sidtis et al, 1981;Volpe et al, 1982;Risse et al, 1989;Eliassen et al, 1999;Marzi et al, 1999), whereas timing coordination is altered by anterior callosotomy (Preilowski, 1972(Preilowski, , 1975Eliassen et al, 1999). Also, the evaluation of the crossed-uncrossed difference in simple reaction times with visual stimuli, to measure the interhemispheric transmission time, cannot be extended to auditory stimuli because there is an almost simultaneous access of auditory information to both hemispheres (Iacoboni and Zaidel, 1999).…”

Section: Discussionmentioning

confidence: 99%

Callosal Contributions to Simultaneous Bimanual Finger Movements

Tacchino²,

et al. 2008

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Corpus callosum (CC) is involved in the performance of bimanual motor tasks. We asked whether its functional role could be investigated by combining a motor behavioral study on bimanual movements in multiple sclerosis (MS) patients with a quantitative magnetic resonance diffusion tensor imaging (DTI) analysis of CC, which is shown to be damaged in this disease. MS patients and normal subjects were asked to perform sequences of bimanual finger opposition movements at different metronome rates; then we explored the structural integrity of CC by means of DTI. Significant differences in motor performance, mainly referred to timing accuracy, were observed between MS patients and control subjects. Bimanual motor coordination was impaired in MS patients as shown by the larger values of the interhand interval observed at all the tested metronome rates with respect to controls. Furthermore, DTI revealed a significant reduction of fractional anisotropy (FA), indicative of microstructural tissue damage, in the CC of MS patients. By correlating the mean FA values with the different motor behavior parameters, we found that the degree of damage in the anterior callosal portions mainly influences the bimanual coordination and, in particular, the movement phase preceding the finger touch. Finally, the described approach, which correlates quantitative measures of tissue damage obtained by advanced magnetic resonance imaging tools with appropriate behavioral measurements, may help the exploration of different aspects of motor performance impairment attributable to the disease.

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“…This notion was built mainly on bimanual coordination deficits observed in patients with extensive lesions of the CC or partial callosotomies (Preilowski, 1972;Jeeves et al, 1988;Andres et al, 1999;Eliassen et al, 1999Eliassen et al, , 2000Wiesendanger and Serrien, 2004;Caille et al, 2005). One step toward a refined understanding of the function of the human CC would be to identify its detailed topographical organization by novel MRI techniques.…”

Section: Introductionmentioning

confidence: 99%

Human Motor Corpus Callosum: Topography, Somatotopy, and Link between Microstructure and Function

Wahl¹,

Lauterbach-Soon²,

Hattingen³

et al. 2007

J. Neurosci.

384

330

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The corpus callosum (CC) is the principal white matter fiber bundle connecting neocortical areas of the two hemispheres. Although an object of extensive research, important details about the anatomical and functional organization of the human CC are still largely unknown. Here we focused on the callosal motor fibers (CMFs) that connect the primary motor cortices (M1) of the two hemispheres. Topography and somatotopy of CMFs were explored by using a combined functional magnetic resonance imaging/diffusion tensor imaging fiber-tracking procedure. CMF microstructure was assessed by fractional anisotropy (FA), and CMF functional connectivity between the hand areas of M1 was measured by interhemispheric inhibition using paired-pulse transcranial magnetic stimulation. CMFs mapped onto the posterior body and isthmus of the CC, with hand CMFs running significantly more anteriorly and ventrally than foot CMFs. FA of the hand CMFs but not FA of the foot CMFs correlated linearly with interhemispheric inhibition between the M1 hand areas. Findings demonstrate that CMFs connecting defined body representations of M1 map onto a circumscribed region in the CC in a somatotopically organized manner. The significant and topographically specific positive correlation between FA and interhemispheric inhibition strongly suggests that microstructure can be directly linked to functional connectivity. This provides a novel way of exploring human brain function that may allow prediction of functional connectivity from variability of microstructure in healthy individuals, and potentially, abnormality of functional connectivity in neurological or psychiatric patients.

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Direction information coordinated via the posterior third of the corpus callosum during bimanual movements

Cited by 94 publications

References 29 publications

The Role of the Corpus Callosum in the Coupling of Bimanual Isometric Force Pulses

The Role of the Corpus Callosum in the Coupling of Bimanual Isometric Force Pulses

Callosal Contributions to Simultaneous Bimanual Finger Movements

Human Motor Corpus Callosum: Topography, Somatotopy, and Link between Microstructure and Function

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