Direction of change in the somatic development in children and adolescents with type 1 diabetes

Kołodziejczyk, Honorata; Wajda-Cuszlag, Małgorzata; Świercz, Anna; Szalecki, Mieczysław

doi:10.18544/pedm-23.02.0078

Cited by 2 publications

(3 citation statements)

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“…However, the subsequent risk of T1DM did not increase in our study. These results are consistent with those of previous studies [31][32][33]. Studies have shown that children with T1DM are more likely to develop allergic disorders (atopic rhinitis, conjunctivitis, and asthma) than the general population.…”

Section: Discussionsupporting

confidence: 93%

“…Studies have shown that children with T1DM are more likely to develop allergic disorders (atopic rhinitis, conjunctivitis, and asthma) than the general population. Kowalczyk et al [32] measured the immunoglobulin E levels of 92 patients with T1DM and found that allergic disorders have a higher prevalence in patients with T1DM. A Turkish study showed that patients with T1DM developed more asthmatic symptoms than the general population.…”

Section: Discussionmentioning

confidence: 99%

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Risk of Type 1 Diabetes Mellitus in Patients with Atopic Dermatitis: A Nationwide Population-Based Cohort Study

Li,

Wu,

Chang

et al. 2023

Dermatology

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Background: Atopic dermatitis (AD) is a disease frequently occurring in children. The immune response is characterized by T-helper (Th)-2-dependent inflammation. Type 1 diabetes mellitus (T1DM) is an autoimmune disease that destroys pancreatic islet beta cells. In contrast, it is mainly mediated by a T-helper (Th)-1-dependent response. An inverted association has been hypothesized between T1DM and AD since Th1 and Th2 responses are mutually inhibitory. Methods: Data was retrieved from a nationwide healthcare database in Taiwan. A logistic regression model was used to evaluate the association of T1DM in patients with AD within a year. A Cox proportional hazards analysis was used to evaluate the subsequent risk of developing T1DM one year after AD diagnosis. Results: We identified 396,461 patients with AD and 1,585,844 age- and sex-matched controls. During the first year of follow-up, after adjusting variates, the association between T1DM and AD showed no statistical differences (odds ratio [OR]: 1.40; 95% confidence interval [CI]: 0.83–2.38, P = 0.207). After excluding those T1DM cases within one year of AD diagnosis and those with a follow-up duration of less than one year, AD did not significantly increase the risk of T1DM (hazard ratio [HR]: 1.02; 95% CI, 0.83–1.25, P = 0.843). Conclusions: Our study revealed that there was no significant association between AD and T1DM in the first year after AD diagnosis, and there was no increased risk of T1DM in AD patients thereafter.

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Section: Discussionsupporting

confidence: 93%

Section: Discussionmentioning

confidence: 99%

Risk of Type 1 Diabetes Mellitus in Patients with Atopic Dermatitis: A Nationwide Population-Based Cohort Study

Li,

Wu,

Chang

et al. 2023

Dermatology

View full text Add to dashboard Cite

show abstract

“…The study was performed on 3 continents by Phelan et al in 2016 [6]. It is worth noting that in the Polish study of Kołodziejczyk et al body mass index in girls was also higher and indicated overweight while in boys it was normal [7]. The higher BMI in girls may by caused by multiple factors such as the influence of sex hormones on parameters of carbohydrate metabolism, low level of physical activity, and concomitance of depressive disorders in comparison to boys [5][6][7][8][9].…”

Section: Discussionmentioning

confidence: 99%