2018
DOI: 10.15275/rusomj.2018.0404
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Directional functional coupling during limbic seizures in rats revealed by nonlinear Granger causality

Abstract: Subject and Purpose -Temporal lobe epilepsy is increasingly recognized to involve widespread network alterations. In this study the temporal dynamics of directional interactions between the frontal cortex, hippocampus, thalamus and midbrain during limbic seizures are analyzed in rats. Methods -Local field potentials were recorded in Wistar rats expressing generalized limbic seizures, Racine's stage 4-5. These spontaneous seizures occur during chronic treatment with a CB1 (cannabinoid receptor type 1) antagonis… Show more

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