Directional growth of octacalcium phosphate using micro-flow reactor mixing and subsequent aging

Saengdet, Ploypailin; Ogawa, Makoto

doi:10.1039/d1ra00827g

Cited by 5 publications

(1 citation statement)

References 69 publications

(88 reference statements)

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“…The HRTEM images of the ribbon particles showed a lattice stripe spacing of 0.81 nm and 0.34 nm (Figure S3), corresponding to (010) and (002) crystal planes, confirming the orientation of the ribbon OCP. The striped particles obtained after magnetic field treatment have more diffraction spots and higher crystallinity [27][28][29][30].…”

Section: Effect Of External Magnetic Field On the Size And Shape Of Ocpmentioning

confidence: 99%

Mineralization of Octacalcium Phosphate under Magnetic Field

He,

Xue,

Qian

et al. 2024

Crystals

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The mineralization of octacalcium phosphate (OCP) crystals in gel media was studied in the presence of a magnetic field. OCP crystal growth was found to be dependent on mineralization temperature, mineralization time, and the magnetic field. Higher temperatures significantly reduced the mineralization time, which is crucial for directional growth of OCP crystals. The growth of OCP crystals was accelerated by the applied magnetic field, while OCP crystals generated in the presence of a magnetic field exhibited increased length and width of oriented growth. This study provides valuable insights into the influence of mineralization factors in bioprocessing-inspired manufacturing processes.

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Section: Effect Of External Magnetic Field On the Size And Shape Of Ocpmentioning

confidence: 99%

Mineralization of Octacalcium Phosphate under Magnetic Field

He,

Xue,

Qian

et al. 2024

Crystals

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Ultrafast and Reproducible Synthesis of Tailor-Made Octacalcium Phosphate

Choudhary,

Indurkar,

Rubenis

et al. 2024

ACS Omega

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Octacalcium phosphate (OCP) has excellent bone formation ability and a good resorption rate as compared to the commercial bone substitutes [e.g., Bio-Oss (Geistlich Pharma AG) and MBCP+ (Biomatlante)], as well as synthesized biomaterials (hydroxyapatite and tricalcium phosphate). The synthesis approach to obtain phase-pure OCP possesses a great challenge due to its complex reaction mechanism and narrow synthesis window. Thus, the current study aimed to overcome the synthesis challenges and to define the precise reaction conditions required for controllable and reproducible synthesis of OCP. Using the principles of the coprecipitation method, novel synthesis protocols were developed ensuring ultrafast synthesis of OCP within minutes. XRD analysis confirmed that phase-pure OCP was obtained. These processing schemes enabled the synthesis of tailor-made OCP with specific surface areas ranging from 16 to 91 m2/g. The synthesized OCPs exhibited plate-like morphology. The interaction of the synthesized OCPs with MC3T3-E1 cells was found to be nontoxic, confirming their cytocompatibility. The synthesis approach developed in this study indicates that challenges such as the reaction volume, stirring rate, and flow rate need to be addressed in the future to upscale the technology.

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Enhancement in Corrosion Resistance and Biocompatibility of Magnesium Alloy Employing Plasma Spray Coating Technique

Aamir,

Rafique,

Razaq

et al. 2023

Preprint

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Directional growth of octacalcium phosphate using micro-flow reactor mixing and subsequent aging

Abstract: Well-defined octacalcium phosphate particles with varied size and aspect ratio were prepared by a micro-flow reactor mixing and subsequent aging in different temperature and aging time.

Cited by 5 publications

References 69 publications

Mineralization of Octacalcium Phosphate under Magnetic Field

Mineralization of Octacalcium Phosphate under Magnetic Field

Ultrafast and Reproducible Synthesis of Tailor-Made Octacalcium Phosphate

Enhancement in Corrosion Resistance and Biocompatibility of Magnesium Alloy Employing Plasma Spray Coating Technique

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