Directionally Encoded Color Track Density Imaging in Brain Tumor Patients: A Potential Application to Neuro-Oncology Surgical Planning

Sullivan, Jared  J.; Zekelman, Leo; Zhang, Fan; Juvekar, Parikshit; Torio, Erickson; Bunevičius, Adomas; Essayed, Walid Ibn; Bastos, Dhiego Chaves de Almeida; He, Jianzhong; Rigolo, Laura; Golby, Alexanda J.; O&apos;Donnell, Lauren J.

doi:10.2139/ssrn.4348551

Cited by 1 publication

(3 citation statements)

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“…The color-coded TDI map scored significantly higher than the traditional color-coded FA map for both questions, with the largest effect size being in the score for establishing target resection margins. 38 The identification of the invasion of indistinct white matter tracts distant from the lesion in glioblastoma poses a challenge to the determination of the extent of resection. 50 The recognition of such invasions is crucial as they can lead to recurrence; however, the accurate identification of their extent is often challenging.…”

Section: Tractography In Surgical Planning For Gliomasmentioning

confidence: 99%

“…8). Other useful tracking techniques that have been proposed for neurosurgical preoperative planning include TDI for better visualization of peritumoral white matter tracts 38 and bicompartment free water modeling algorithms for improved peritumoral edema tracking. 55 Incorporating these advanced pieces of technology into navigation software programs can enhance postoperative outcomes.…”

Section: Current Issues and Future Directionsmentioning

confidence: 99%

“…This preference was driven by the visualization of clinically relevant tracts in the peritumoral region; that is, areas of T1/T2 signal change, as demonstrated by the DEC-FA map. Adapted with permission from Sullivan et al38…”

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confidence: 99%

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Advancements in Diffusion MRI Tractography for Neurosurgery

Kamagata,

Andica,

Uchida

et al. 2023

Invest Radiol

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Diffusion magnetic resonance imaging tractography is a noninvasive technique that enables the visualization and quantification of white matter tracts within the brain. It is extensively used in preoperative planning for brain tumors, epilepsy, and functional neurosurgical procedures such as deep brain stimulation. Over the past 25 years, significant advancements have been made in imaging acquisition, fiber direction estimation, and tracking methods, resulting in considerable improvements in tractography accuracy. The technique enables the mapping of functionally critical pathways around surgical sites to avoid permanent functional disability. When the limitations are adequately acknowledged and considered, tractography can serve as a valuable tool to safeguard critical white matter tracts and provides insight regarding changes in normal white matter and structural connectivity of the whole brain beyond local lesions. In functional neurosurgical procedures such as deep brain stimulation, it plays a significant role in optimizing stimulation sites and parameters to maximize therapeutic efficacy and can be used as a direct target for therapy. These insights can aid in patient risk stratification and prognosis. This article aims to discuss state-of-the-art tractography methodologies and their applications in preoperative planning and highlight the challenges and new prospects for the use of tractography in daily clinical practice.

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Section: Tractography In Surgical Planning For Gliomasmentioning

confidence: 99%

Section: Current Issues and Future Directionsmentioning

confidence: 99%