Directly Compressed Mini Matrix Tablets Containing Ibuprofen: Preparation and Evaluation of Sustained Release

Lopes, Carla Martins; Lobo, José Manuel Sousa; Costa, Paulo Jorge Cardoso da; Pinto, João F.

doi:10.1080/03639040500388482

Cited by 42 publications

(31 citation statements)

References 28 publications

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“…Similar phenomena were observed by Lopes et al 12 and Papadimitriou et al, 21 who related the predominantly axial relaxation of the HPMC compacts to the relief of stress induced during compaction and the unidirectional swelling to the orientation of the molecules during compression. The reason for such preferential swelling in an axial direction must be due to the need for the directional stresses, imposed on HPMC during tableting, to relax.…”

Section: Liquid Uptake and Erosionsupporting

confidence: 70%

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Design and evaluation of matrix-based controlled release tablets of diclofenac sodium and chondroitin sulphate

Avachat

Kotwal²

2007

AAPS PharmSciTech

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The purpose of the present study was to develop and characterize an oral controlled release drug delivery system for concomitant administration of diclofenac sodium (DS) and chondroitin sulfate (CS). A hydrophilic matrix-based tablet using different concentrations of hydroxypropylmethylcellulose (HPMC) was developed using wet granulation technique to contain 100 mg of DS and 400 mg of CS. Formulations prepared were evaluated for the release of DS and CS over a period of 9 hours in pH 6.8 phosphate buffer using United States Pharmacopeia (USP) type II dissolution apparatus. Along with usual physical properties, the dynamics of water uptake and erosion degree of tablet were also investigated. The in vitro drug release study revealed that HPMC K100CR at a concentration of 40% of the dosage form weight was able to control the simultaneous release of both DS and CS for 9 hours. The release of DS matched with the marketed CR tablet of DS with similarity factor (f 2 ) above 50. Water uptake and erosion study of tablets indicated that swelling followed by erosion could be the mechanism of drug release. The in vitro release data of CS and DS followed KorsmeyerPeppas and zero-order kinetics, respectively. In conclusion, the in vitro release profile and the mathematical models indicate that release of CS and DS can be effectively controlled from a single tablet using HPMC matrix system.

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Section: Liquid Uptake and Erosionsupporting

confidence: 70%

“…12 The degree of erosion (expressed as percentage erosion of the polymer content, E) was determined using Equation 2:…”

Section: Quantification Of the Water Uptake And Erosion Determinationmentioning

confidence: 99%

Design and evaluation of matrix-based controlled release tablets of diclofenac sodium and chondroitin sulphate

Avachat

Kotwal²

2007

AAPS PharmSciTech

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“…During swelling of the tablets, an anisotropic swelling phenomena (that is, more swelling in the axial direction than in the radial direction on exposure to water) was seen. In previous studies conducted by Lopes et al (2006) and Papadimitriou et al (1993) similar phenomenon were observed. The reason for such preferential swelling in an axial direction may be due to the need for directional stresses imposed during tableting to relax.…”

Section: Liquid Uptake and Erosion Of Polymersupporting

confidence: 65%

Novel modified release tableted microspheres of ibuprofen and misoprostol in a combined formulation: Use of software DDSolver

Akhtar

Ahmad²,

Khan³

et al. 2012

Afr. J. Pharm. Pharmacol.

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The current study was aimed to develop a stable sustained release drug delivery system for ibuprofen and a cytoprotective agent misoprostol in a combined dosage form. Non-aqueous emulsion solvent evaporation method was used to prepare ibuprofen microspheres. Ethylcellulose (EC) and Hydroxypropyl methylcellulose (HPMC) were used as the release retarding polymers in combination. Ibuprofen microspheres were prepared separately and then compressed into tablet dosage forms with misoprostol dispersions in HPMC. For surface topography of microspheres, Scanning Electron Microscope (SEM) was used. Fourier transformed infrared (FTIR) spectroscopy and X-ray diffractometry (XRD) were employed to evaluate pharmaceutical incompatibility and physical state of drug in formulation. The mechanism and pattern of drug release were determined by applying kinetic models. Tableted microspheres were also assessed for accelerated stability study for three months. SEM showed spherical shape microspheres. FTIR and XRD data for developed formulation indicated stability and compatibility of drugs with excipients. After 10 h, 86.97 and 89.33% of ibuprofen and misoprostol were released from micro particles while 75.43 and 77.65% from tableted microspheres, respectively. Non-aqueous emulsion solvent evaporation was found to be a suitable method to prepare stable sustained release tableted microspheres of ibuprofen and misoprostol in combination.

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“…Several matrix based sustained release products of aceclofenac utilizing hydrophilic and hydrophobic polymers have been reported [7][8][9][10][11][12][13]. Polymer matrix systems have the advantages of prolonging drug release and reducing adverse effects in patients.…”

Section: Introductionmentioning

confidence: 99%

Formulation and in Vitro Evaluation of Once Daily Sustained Release Formulation of Aceclofenac

Ghosh¹,

Barik²

2010

Trop. J. Pharm Res

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Purpose: The objective of the study was to develop matrix tablets for oral controlled release of aceclofenac using ethyl cellulose, guar gum and various grades of cellulose polymers. Methods: Possible drug-excipient interaction was evaluated by high performance liquid chromatography (HPLC) and Fourier infrared spectroscopy (FTIR). The tablets prepared were assessed for their physicochemical, in vitro drug release at pH1.2, 4.5, 6.8 and 7.5 and stability characteristics. Comparison with a 'once daily' commercial aceclofenac product was made in the in vitro studies. Results: There was no interaction between aceclofenac and the polymers used as excipients. Furthermore, the physicochemical properties of the tablets were satisfactory. The release profile of one of the formulated aceclofenac tablets (F7), which contained hydroxypropyl methyl cellulose (HPMC K4M), was statistically similar (p < 0.05) to that of the commercial aceclofenac brand in all the dissolution media. The formulated products ware stable and showed no changes in physical appearance, drug content, or dissolution pattern after storage at 40 o C /75 %RH for 6 months. Conclusion:The results indicate that it is feasible to achieve a stable 'once daily' sustained release aceclofenac tablet formulation by using HPMC K4M of 4000cps viscosity grade as matrix material.

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Directly Compressed Mini Matrix Tablets Containing Ibuprofen: Preparation and Evaluation of Sustained Release

Cited by 42 publications

References 28 publications

Design and evaluation of matrix-based controlled release tablets of diclofenac sodium and chondroitin sulphate

Design and evaluation of matrix-based controlled release tablets of diclofenac sodium and chondroitin sulphate

Novel modified release tableted microspheres of ibuprofen and misoprostol in a combined formulation: Use of software DDSolver

Formulation and in Vitro Evaluation of Once Daily Sustained Release Formulation of Aceclofenac

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