Directly injected native bone-marrow stem cells cannot incorporate into acetaminophen-induced liver injury

Babaei, Azadeh; Katoonizadeh, A.; Ranjbar, Azam; Naderi, Mahmood; Ahmadbeigi, Naser

doi:10.1016/j.biologicals.2017.12.006

Cited by 3 publications

(3 citation statements)

References 25 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…According to our published data [21,22] and the results of other researchers [19,20,23,24], most of the MSCs injected into tissues remain viable for a very short time. A sharp change in the microenvironment of cell existence, the transition from comfortable conditions of in vitro cultivation to completely different conditions of in vivo functioning contribute to the death of a significant portion of the injected MSCs.…”

Section: Discussionmentioning

confidence: 75%

“…Along with this, there is evidence in the literature that after injection into tissues, the MSCs die very quickly due to a sharp change in the microenvironment [19][20][21][22][23][24]. In addition, all works devoted to the effect of MSCs and their exosomes on the liver and reporting a good therapeutic efficacy of cell therapy do not contain any data on the possible complications and side effects of MSCs.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Some Special Aspects of Liver Repair after Resection and Administration of Multipotent Stromal Cells in Experiment

Maiborodin

Лушникова

Клинникова

et al. 2021

Life

View full text Add to dashboard Cite

Changes in rat liver after resection and injection of autologous multipotent mesenchymal stromal cells of bone marrow origin (MSCs) transfected with the GFP gene and cell membranes stained with red-fluorescent lipophilic membrane dye were studied by light microscopy. It was found that after the introduction of MSCs into the damaged liver, their differentiation into any cells was not found. However, under the conditions of MSCs use, the number of neutrophils in the parenchyma normalizes earlier, and necrosis and hemorrhages disappear more quickly. It was concluded that the use of MSCs at liver resection for the rapid restoration of an organ is inappropriate, since the injected cells in vivo do not differentiate either into hepatocytes, into epithelial cells of bile capillaries, into endotheliocytes and pericytes of the vascular membranes, into fibroblasts of the scar or other connective tissue structures, or into any other cells present in the liver.

show abstract

Section: Discussionmentioning

confidence: 75%

Section: Introductionmentioning

confidence: 99%

Some Special Aspects of Liver Repair after Resection and Administration of Multipotent Stromal Cells in Experiment

Maiborodin

Лушникова

Клинникова

et al. 2021

Life

View full text Add to dashboard Cite

show abstract

“…Another hurdle to overcome in cell therapy for liver regeneration is the low cell engraftment and survival post-transplantation [74]. Babaei et al showed, for example, that even direct injection of bone marrow-derived aggregates into acute damaged liver did not show longlasting incorporation of the bone marrow cells [75]. Moreover, allogenic hepatocyte transplantation should be still followed by an immunosuppressive therapy used for OLT [44,74,76].…”

Section: Pitfalls and Hurdles To Overcome In Liver Cell Therapiesmentioning

confidence: 99%

Liver Bioengineering: Promise, Pitfalls, and Hurdles to Overcome

2019

View full text Add to dashboard Cite

Purpose of Review-In this review, we discuss the recent advancements in liver bioengineering and cell therapy and future advancements to improve the field towards clinical applications. Recent Findings-3D printing, hydrogel-based tissue fabrication, and the use of native decellularized liver extracellular matrix as a scaffold are used to develop whole or partial liver substitutes. The current focus is on developing a functional liver graft through achieving a nonleaky endothelium and a fully constructed bile duct. Use of cell therapy as a treatment is less invasive and less costly compared to transplantation, however, lack of readily available cell sources with low or no immunogenicity and contradicting outcomes of clinical trials are yet to be overcome. Summary-Liver bioengineering is advancing rapidly through the development of in vitro and in vivo tissue and organ models. Although there are major challenges to overcome, through optimization of the current methods and successful integration of induced pluripotent stem cells, the development of readily available, patient-specific liver substitutes can be achieved.

show abstract

Stem Cell Therapy as a Potential Treatment of Non-Alcoholic Steatohepatitis-Related End-Stage Liver Disease: A Narrative Review

Mahmoudi,

Meidany,

Almahmeed

et al. 2024

Curr Stem Cell Rep

View full text Add to dashboard Cite

Directly injected native bone-marrow stem cells cannot incorporate into acetaminophen-induced liver injury

Cited by 3 publications

References 25 publications

Some Special Aspects of Liver Repair after Resection and Administration of Multipotent Stromal Cells in Experiment

Some Special Aspects of Liver Repair after Resection and Administration of Multipotent Stromal Cells in Experiment

Liver Bioengineering: Promise, Pitfalls, and Hurdles to Overcome

Stem Cell Therapy as a Potential Treatment of Non-Alcoholic Steatohepatitis-Related End-Stage Liver Disease: A Narrative Review

Contact Info

Product

Resources

About