Introduction: Endotracheal intubation is the gold standard for providing adequate ventilation. During laryngoscopy and endotracheal intubation, airway stimulation results in reflex sympathetic system activation and unfavorable hemodynamic response. We aimed to evaluate the effect of videolaryngoscope (C-MAC VL) and conventional Macintosh direct laryngoscopy (DL) applications in endotracheal intubation under general anesthesia on hemodynamic response and time duration in patients with and without hypertensive. Method: Normotensive (n=100) and hypertensive (n=100), aged between 18 and 75 years old (ASA I-II) who were scheduled to undergo elective surgery under general anesthesia, were included in the prospective study. Hypertensive patients were further divided into two subgroups; those intubated with videolaryngoscopy (group HV, n=50) and those with conventional direct laryngoscopy (group HD, n=50). Normotensive patients were also divided into two subgroups as videolaryngoscopy subgroup (group NV, n=50) and conventional direct laryngoscopy subgroup (group ND, n=50). Hemodynamic parameters, airway evaluation measurements, procedure duration and patients demographic characteristics were recorded. Results: There was no significant change in the hemodynamic parameters other than heart rate in the four groups compared to baseline measurements. The median intubation time of all videolaryngoscopy group (HV and NV) (10 sec) was shorter than that of all direct laryngoscopy group (HD and ND) (11.5 sec). Conclusion: Hemodynamic response behaves alike in all goups. However, intubation time takes least amount of time with the C-MAC VL than the conventional Macintosh DL. We think that using VL during intubation is practical and useful in the cases with sudden loss of consciousness, in which airway tone cannot be maintained.