Disability-adjusted life-years and mortality rate for colorectal cancer attributable to dietary risk in Middle East and North African from 1990–2019

Abstract

Background: Colorectal cancer (CRC) in low-income and middle-income countries, there is an increasing trend. This study aimed to estimate the burden of CRC attributable to dietary risk in the Middle East and North Africa (MENA) region.Method: In current study, data of the Global Burden of Disease (GBD) 2019 study were used to estimate the age-standardized mortality rates (ASMR) and disability-adjusted life-years (DALYs). We evaluated the 30-year trend of DALYs and mortality rate of CRC attributable to dietary risk, from 1990 to 2019 by sex and age groups, in 21 countries of MENA region.Results: Percent changes ASMR attributed to dietary risk for CRC in men and women were 8.32% and 3.44%, respectively. The percent changes related to DALYs/100,000 in men and women was 8.15% and 2.50%, respectively. The highest DALYs and ASMR were in the age group of 75-79. The highest percent changes of DALYs/100,000 and ASMR was observed in Afghanistan, Egypt, Iran, Iraq, Lebanon, Libya, Morocco, Palestine, Qatar, Saudi Arabia, Sudan and Yemen from 1990 to 2019. Trend of ASMR and DALYs attributed to diet high in red meat; low in calcium, low in milk, low in fiber and low in whole grain risk have been increasing for CRC.Conclusion: The DALYs and ASMR attributed to dietary risk for CRC has increased in 21 countries of the MENA regions from 1990 to 2019. Dietary modification with increasing fiber, dairy products and reducing red meat intake are highly recommended strategies in preventing CRC.