Disability and life satisfaction in neurological disorders: The role of depression and perceived cognitive difficulties

Gandy, Milena; Heriseanu, Andreea I.; Dudeney, Joanne; Bisby, Madelyne A.; Scott, Allan; Fisher, Alana; Hathway, Taylor; Karin, Eyal; Titov, Nickolai; Dear, Blake F.

doi:10.1016/j.genhosppsych.2021.08.013

Cited by 9 publications

(4 citation statements)

References 53 publications

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“…The results from this study provide the first direct evidence that people living with the most common variant of MS (RRMS) report a level of OHRQoL that is significantly poorer than demographically matched controls. These results therefore align with a much broader literature which shows that quality of life is typically reduced in RRMS, 12 but meaningfully extends it to show that this effect also emerges in the specific domain of oral health.…”

Section: Discussionsupporting

confidence: 89%

“…Broader literature also reveals that neuropsychiatric signs and symptoms such as depression and anxiety present frequently in MS, 9 and may not simply reflect a response to living with a chronic disease, but a multifactorial aetiology that includes MS‐related structural and functional brain impairment. 10 Because higher levels of depression and anxiety in people living with MS have been shown to influence patient‐reported cognitive complaints 11 as well as patient‐reported quality of life, 12 mental health may therefore contribute to poor OHRQoL in this group.…”

Section: Introductionmentioning

confidence: 99%

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Oral health‐related quality of life is more strongly correlated with mental health than with oral health in relapsing–remitting multiple sclerosis

Henry

Manchery

Swayne

et al. 2022

J of Oral Rehabilitation

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Background: Multiple sclerosis (MS) is a leading cause of neurological disability in young and middle-aged populations, associated with substantial burden of illness.Because a growing literature now shows that this burden extends to poorer oral health, oral health-related quality of life (OHRQoL) may be reduced as well.Objectives: To test whether people with relapsing-remitting MS (RRMS) have poorer OHRQoL than demographically matched controls, and to establish which variables are associated with worse OHRQoL. Materials and Methods:In total, 64 people with RRMS and 69 demographically matched controls participated. Both groups completed the Oral Health Impact Profile (OHIP-14), a validated measure of OHRQoL, as well as an objective oral health examination performed by a qualified dentist, a measure of dental-related functionality and a measure of mental health.Results: OHRQoL was significantly poorer in the RRMS relative to the control group.However, although poorer OHRQoL in the RRMS group was moderately associated with objectively assessed oral health (r = .30), it was more strongly associated with mental health (r = .61). For the control group, the reverse pattern of association was evident, with OHRQoL more strongly associated with oral health (r = .48) relative to mental health (r = .20). Conclusion:People with RRMS report poorer OHRQoL than demographically matched controls, but these appraisals are more strongly linked to mental health than to objective oral health indicators. K E Y W O R D S multiple sclerosis, neurological disorder, oral health, oral health-related quality of life, wellbeing | 63 NANGLE et al. How to cite this article: Nangle MR, Manchery N, Swayne A, Boocock H, Blum S, Henry JD. Oral health-related quality of life is more strongly correlated with mental health than with oral health in relapsing-remitting multiple sclerosis.

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Section: Discussionsupporting

confidence: 89%

Section: Introductionmentioning

confidence: 99%

Oral health‐related quality of life is more strongly correlated with mental health than with oral health in relapsing–remitting multiple sclerosis

Henry

Manchery

Swayne

et al. 2022

J of Oral Rehabilitation

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“…These findings align with existing literature (Rae-Grant et al, 2018;Wei, Ma, Li, & Zhang, 2021), emphasizing the psychological challenges faced by MS patients. The presence of anxiety and depression symptoms further underscores the importance of addressing psychological well-being in MS management, as these symptoms can significantly impact overall QoL (Bishop, Rumrill Jr, & Roessler, 2015;Gandy et al, 2021;Motl & McAuley, 2010;Young et al, 2022). In terms of social well-being, the study revealed that MS patients in the sample reported moderate levels of social functioning, the impact of physical health on social activities, and the ability to engage in social relationships.…”

Section: Discussionmentioning

confidence: 90%

Exploring Quality of Life in Patients with Multiple Sclerosis: A Multidimensional Perspective

H Ibrahim,

Mahmood

2024

MJN

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Background: This study aimed to investigate the quality of life (QoL) in patients with multiple sclerosis (MS) from Al Salm Teaching Hospitals in the city of Mosul. Methods: A sample of 500 MS patients was included in the study, and their QoL was assessed using validated measurement tools for physical, psychological, and social well-being. Descriptive statistics and correlation analyses were conducted to examine the relationships between different dimensions of QoL and symptoms of anxiety and depression. Results: The results indicated that MS patients reported moderate levels of physical, psychological, and social well-being. Specifically, physical well-being was characterized by moderate levels of physical functioning, bodily pain, and general health perception. Psychological well-being was moderate in terms of vitality, social functioning, and emotional role limitations. Social well-being was also at a moderate level, considering social functioning and the impact of physical health on social activities and relationships. However, anxiety and depression symptoms were prevalent and negatively affected all aspects of QoL. Conclusion: The findings highlight the complex nature of QoL in MS patients and the importance of addressing physical, psychological, and social well-being in their management. The results are consistent with previous research, emphasizing the universal challenges faced by MS patients. The study underscores the need for targeted interventions and comprehensive support systems to improve the QoL of MS patients.

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“…Depression and anxiety are highly prevalent among people with neurological disorders (Hesdorffer, 2016 ) and substantially increase burden of disease. Poor mental health can disrupt the medical management, self-management, quality of life, and prognosis of neurological disorders (Gandy et al, 2021 ; Hesdorffer, 2016 ; Patel et al, 2016 ). In addition, neurological disorders are often associated with significant disability, especially difficulties with cognitive function.…”

mentioning

confidence: 99%

The wellbeing neuro course: a randomised controlled trial of an internet-delivered transdiagnostic psychological intervention for adults with neurological disorders

Gandy

Heriseanu²,

Balakumar³

et al. 2023

Psychol. Med.

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Background Mental health and functional difficulties are highly comorbid across neurological disorders, but supportive care options are limited. This randomised controlled trial assessed the efficacy of a novel transdiagnostic internet-delivered psychological intervention for adults with neurological disorders. Methods 221 participants with a confirmed diagnosis of epilepsy, multiple sclerosis, Parkinson's disease, or an acquired brain injury were allocated to either an immediate treatment group (n = 115) or treatment-as-usual waitlist control (n = 106). The intervention, the Wellbeing Neuro Course, was delivered online via the eCentreClinic website. The Course includes six lessons, based on cognitive behavioural therapy, delivered over 10 weeks with support from a psychologist via email and telephone. Primary outcomes were symptoms of depression (PHQ-9), anxiety (GAD-7) and disability (WHODAS 2.0). Results 215 participants commenced the trial (treatment n = 111; control n = 104) and were included in intention-to-treat analysis. At post-treatment, we observed significant between-group differences in depression (PHQ-9; difference = 3.07 [95% CI 2.04–4.11], g = 0.62), anxiety (GAD-7; difference = 1.87 [0.92–2.81], g = 0.41) and disability (WHODAS 2.0 difference = 3.08 [1.09–5.06], g = 0.31), that favoured treatment (all ps < 0.001). Treatment-related effects were maintained at 3-month follow-up. Findings were achieved with minimal clinician time (average of 95.7 min [s.d. = 59.3] per participant), highlighting the public health potential of this approach to care. No adverse treatment events were reported. Conclusions Internet-delivered psychological interventions could be a suitable model of accessible supportive care for patients with neurological disorders.

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Disability and life satisfaction in neurological disorders: The role of depression and perceived cognitive difficulties

Cited by 9 publications

References 53 publications

Oral health‐related quality of life is more strongly correlated with mental health than with oral health in relapsing–remitting multiple sclerosis

Oral health‐related quality of life is more strongly correlated with mental health than with oral health in relapsing–remitting multiple sclerosis

Exploring Quality of Life in Patients with Multiple Sclerosis: A Multidimensional Perspective

The wellbeing neuro course: a randomised controlled trial of an internet-delivered transdiagnostic psychological intervention for adults with neurological disorders

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