Objective: to substantiate the significance of quality of life indicators in the formation of modern content of personalized rehabilitation of patients with a consequences of traumatic brain injury. Material and methods. The study included 414 respondents of working age (93.6% men). 54% of the respondents had a traumatic brain injury within 1 to 5 years, in 62,0%, cases the traumatic brain injury was of severe degree. Longitudinal sociological study of the quality of life using the WHOQOL-100 questionnaire was carried out. The Dembo-Rubinstein test was used to diagnose the adequacy of self-assessment of the respondents with TBI. The dynamics of the respondents' neurological status and quality of life were assessed annually during 2020-2022. Results. In the annual study, 64.7% of respondents showed clinical deterioration in 96% of cases, which was manifested by increased severity of general cerebral symptoms, cognitive impairment, and asthenic syndrome. In 4.0% of cases new symptoms manifested (posttraumatic epilepsy). In the dynamic of respondents' quality of life, clinical deterioration in parameters "Physical sphere", "Psychological sphere", "Environment" and "General quality of life and health status" was revealed. Conclusion. In the absence of specific laboratory markers in clinical practice and not always sufficient informativeness of neuroimaging methods for the verification of the consequences of traumatic brain injury, the quality of life can be considered as an important criterion of prognosis, which determines the content of personalised rehabilitation of patients with the consequences of traumatic brain injury.