Disaccharidases of the Gastric Mucosa in Chronic Atrophic Gastritis with Intestinal Metaplasia

Claßen, Martin; Hinüber, G. von; Demling, L

doi:10.1159/000196831

Cited by 6 publications

(2 citation statements)

References 6 publications

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“…This view is supported by the evidence presented by C lassen [2] that in patients with atrophic gastritis and intestinal metaplasia, similar changes may be observed in the disaccharidase content of the gastric juice. This conclusion of ours supplied and acceptable answer to problem one in our working hypo thesis, that of the 'false positive' results.…”

Section: Discussionsupporting

confidence: 63%

Diagnostic Value of Determination of Lactate Dehydrogenase and β-Glucuronidase Activity of Gastric Juice

Szabó¹,

Figus²

1972

Digestion

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The diagnostic value of lactate dehydrogenase (LDH) and β-glucuronidase (β-glu.) activity assays in the gastric juice are assessed by the authors, relying upon the evidence obtained in 400 cases. The authors sought the cause of the ‘false positive’ results making the tests unreliable beforehand. In the authors’ opinion, LDH and β-glu. activities depend on the general condition of the gastric mucosa; LDH activity increases parallel with the severity of gastric glandular atrophy, and β-glu. activity is increased in the presence of malignant tumours and in intestinal metaplasia only. The enzyme studies may be utilized in differentiating gastric cancer and chronic gastritis from other gastric diseases, on the one hand, and, on the other, they may help screen out cases of chronic atrophic gastritis and intestinal metaplasia, which may be considered to be preneoplastic conditions.

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Section: Discussionsupporting

confidence: 63%

Diagnostic Value of Determination of Lactate Dehydrogenase and β-Glucuronidase Activity of Gastric Juice

Szabó¹,

Figus²

1972

Digestion

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“…Absorptive enterocytes are the most important for the intestinal epithelial cells because the main function of the small intestine is to digest food and absorb nutrients. Disaccharidase activities specific to absorptive enterocytes such as sucrase, maltase, trehalase and lactase were reported in human intestinal metaplastic mucosa, using specimens obtained by gastrectomy or endoscopic gastric biopsy (Classen et al, 1968) (Launiala and Siurala, 1968) (Capoferro, 1972) (Kawachi et al, 1974) (Gudmand-Hoyer et al, 1975. Cdx2 has been reported to regulate the expression of various genes specific to absorptive enterocytes in the intestine such as sucrase-isomaltase (Suh and Traber, 1996), lactase-phlorizin hydrolase (Troelsen et al, 1997), calbindin-D9K (Colnot et al, 1998) and carbonic anhydrase I (Drummond Silberg et al, discussed that other factors specific to small intestine might be needed in addition to Cdx2 for the expression of sucrase.…”

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confidence: 99%

Cdx2 specifies the differentiation of morphological as well as functional absorptive enterocytes of the small intestine

Mutoh

Satoh²,

Kita³

et al. 2005

Int. J. Dev. Biol.

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Many transcription factors are involved in the molecular control of intestinal epithelial cell differentiation. We report in this study that the transcription factor Cdx2 functions to define absorptive enterocytes during intestinal epithelial differentiation. Cdx2 is expressed in the villi of the normal small intestine. Intestinal metaplasia, which expresses Cdx2, occurs as a pathological condition in gastric mucosa. We have previously established Cdx2 transgenic mice expressing Cdx2 exclusively in the gastric epithelium. In this study using Cdx2 transgenic mice, we show that Cdx2 plays a key role in the differentiation of intestinal absorptive enterocytes. The gastric mucosa of Cdx2 transgenic mice was morphologically completely changed into intestinal metaplastic mucosa. Absorptive enterocytes had microvilli which were observed by electron microscope. The intestinal metaplastic mucosa of Cdx2 transgenic mice expressed sucrase and peptide transporter PepT1. Disaccharidase and leucine aminopeptidase activities were observed in the intestinal metaplastic mucosa. Glucose and amino acids were absorbed from Cdx2 transgenic mouse stomach with intestinal metaplasia. Finally we generated mice whose intestine was extensively excised. Cdx2 transgenic mice with intestinal metaplasia survived even after extensive intestinal excision. We successfully demonstrated that Cdx2 induced not only morphological but also functional absorptive enterocytes in the intestinal metaplastic mucosa in vivo. Our results suggest that Cdx2 is necessary and sufficient by itself to specify the development of intestinal absorptive enterocytes, whereas other factors which are expressed in the small intestine are not always necessary for the differentiation of functional absorptive enterocytes.

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Nitrates and Nitrites: Ingestion, Pharmacodynamics, and Toxicology

Hartman

1982

Chemical Mutagens

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Disaccharidases of the Gastric Mucosa in Chronic Atrophic Gastritis with Intestinal Metaplasia

Cited by 6 publications

References 6 publications

Diagnostic Value of Determination of Lactate Dehydrogenase and β-Glucuronidase Activity of Gastric Juice

Diagnostic Value of Determination of Lactate Dehydrogenase and β-Glucuronidase Activity of Gastric Juice

Cdx2 specifies the differentiation of morphological as well as functional absorptive enterocytes of the small intestine

Nitrates and Nitrites: Ingestion, Pharmacodynamics, and Toxicology

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