Disagreement between Skin Prick Tests and Specific IgE in Early Childhood

Chauveau, A.; Dalphin, Marie‐Laure; Kaulek, Vincent; Roduit, Caroline; Pugin, Aurore; Mutius, Erika von; Vuitton, Dominique A.; Dalphin, Jean‐Charles

doi:10.1159/000446776

Cited by 16 publications

(12 citation statements)

References 31 publications

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“…The area under the curve (AUC) obtained with SPT was not significantly different from that obtained with sIgE in recent research made by Chauveau A. et al [10,11]. For asthma and hay fever, SPT (cutoff value at 3 mm) had a significantly higher specificity (P < 0.0001) than sIgE (cutoff value at 0.35 IU/mL) and the specificity was not different between both tests (P=.1088).…”

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confidence: 68%

Diagnostic Value of Methods for Sensitization Determination in People With Allergic Rhinitis (Review of Literature and Own Dat

Bogomolov¹

2019

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Objective was to review the literature on the diagnostic value of various methods for determining sensitization in patients with allergies, to study the parameters of the specificity and sensitivity of skin testing and laboratory determination of specific IgE. Materials and methods. 88 patients with allergic rhinitis were examined by three different methods of specific allergic diagnosis (in vivo and in vitro) in accordance with the guidelines of the ethics committee of the National Pirogov memorial medical university, all were beyond the acute period. The inclusion criteria were allergic rhinitis diagnosis (both intermittent and persistent) with proven sensitivity to domestic allergens. Skin prick test was carried out according to the classical testing procedure in accordance with regulatory documents with commercial extracts of allergens. Western blot testing for specific IgE levels was performed using RIDA qLine test systems (R-Biopharm AG, Darmstadt, Germany) and Euroline (Euroimmun). The sIgE concentration was converted to a nominal scale (grades) according to the following rules: < 0.35 IU mL-1-level 0 (negative), (0.36-0.69) IU mL-1-level 1 (boundary levels), (0.7-3.49) IU mL-1-level 2 (slightly elevated), (3.50-17.4) IU mL-1-level 3 (moderately elevated), (17.5-49,9) IU mL-1-level 4 (high levels), (50-100) IU mL-1-level 5 (very high levels) and > 100 IU mL-1-level 6 (extremely high levels). Results and discussion. The results of two systems for determining the specific IgE to D. Pteronissinus by Rida AllergyScreen and Euroline have a systematic difference in rates (-1.27 kU / l). Between the data of skin testing with D. Pteronissinus allergens and detection of specific IgE by the Rida AllergyScreen method, there is good agreement between the results, there is satisfactory agreement between the results of the research between the data of skin testing with allergens D. Pteronissinus and the detection of specific IgE by the Euroline method.

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confidence: 68%

Diagnostic Value of Methods for Sensitization Determination in People With Allergic Rhinitis (Review of Literature and Own Dat

Bogomolov¹

2019

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“…Serum sIgE emerges as an alternative test in the field of allergy diagnosis. In some countries, for reasons of conformity, it is resorted to an estimate of the atopic state in young children solely by measuring the level of sIgE (circulating IgE) for certain allergens in the serum [2].…”

Section: Markers Of Allergic Status -Skin Prick Test Total and Specimentioning

confidence: 99%

Dependence of the allergic status markers on the level of vitamin D in the serum

Dajic

Stojkovic²,

Novkovic

et al. 2019

Srp Arh Celok Lek

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Introduction/Objective Recent researches show a link between low vitamin D serum levels and increased prevalence of allergic disease. The objective of this study was to show whether there is any dependence of the allergic status markers: skin prick test (SPT), total immunoglobulin E IgE (tIgE), and allergen-specific IgE (sIgE ≥ 3 class) in serum from the serum 25(OH)D (vitDs) level in children with allergic disease/s. Methods A total of 150 children with allergic disease/s were enrolled into this study. The vitDs, tIgE, SPT, and sIgE ≥ 3 class for aeroallergens and common food allergens were simultaneously assessed. Results We found a negative correlation between vitDs level and age groups and a statistically significant positive correlation between vitDs level and tIgE, sIgE ≥ 3 class for hen's egg yolk and hen's egg white. A statistically significant positive correlation was determined between vitDs level and SPT on Dermatophagoides pteronyssinus, and a negative correlation between tIgE and SPT on Dermatophagoides pteronyssinus, as well as between vitDs level and sIgE ≥ 3 class for Cladosporium and Alternaria molds. We confirmed the dependence of nettle rash and comorbidity asthma from the vitamin D insufficiency and vitamin D deficiency. We did not find any dependence of serum tIgE on vitDs level for the sample. Conclusion In order to get an adequate insight into the allergic status in children, we must take into account the pleotropic effects of vitamin D, according to which we suggest that, in the future, vitDs level should be determined synchronously with known markers of allergic status.

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“…While a few studies have shown some discordance between these two methods in adults, most studies were performed in the hospital setting, whereas far fewer studies have compared SPTs and sIgE head‐to‐head in childhood, and fewer still have done so in unselected birth cohorts . The results of a substudy on atopic sensitization in French children from the PASTURE (Protection against Allergy: STUdy in Rural Environment) cohort suggested disagreement between SPT and sIgE in the first 6 years of life …”

Section: Introductionmentioning

confidence: 99%

“…5 The results of a substudy on atopic sensitization in French children from the PASTURE (Protection against Allergy: STUdy in Rural Environment) cohort suggested disagreement between SPT and sIgE in the first 6 years of life. 6 The discordance between these two tests raises the question as to whether one test method is better associated with allergic diseases than the other. Allergic rhinitis is known to be well correlated with both tests, 7 but little is known about other allergic diseases, 8 especially in childhood.…”

mentioning

confidence: 99%

Skin prick tests and specific IgE in 10‐year‐old children: Agreement and association with allergic diseases

Chauveau

Dalphin

Mauny

et al. 2017

Allergy

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Disagreement between Skin Prick Tests and Specific IgE in Early Childhood

Cited by 16 publications

References 31 publications

Diagnostic Value of Methods for Sensitization Determination in People With Allergic Rhinitis (Review of Literature and Own Dat

Diagnostic Value of Methods for Sensitization Determination in People With Allergic Rhinitis (Review of Literature and Own Dat

Dependence of the allergic status markers on the level of vitamin D in the serum

Skin prick tests and specific IgE in 10‐year‐old children: Agreement and association with allergic diseases

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