Disc Haemorrhage and Glaucoma

Bengtsson, Bo; Holmin, Catharina; Krakau, C. E. T.

doi:10.1111/j.1755-3768.1981.tb06703.x

Cited by 129 publications

(39 citation statements)

References 10 publications

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“…The occurence of manifest glaucoma in persons born before 1907, reported here, was consistent with those in persons born after 1906 (Bengtsson 1981a) and in persons with disc haemorrhages (Bengtsson et al 1981) reported elsewhere. Our collected results may be summarized as follows: the annual incidence of manifest glaucoma was 0.2% in women past 55 and men past 65.…”

Section: Discussionsupporting

confidence: 92%

Manifest Glaucoma in the Aged I: Occurrence Nine Years After a Population Survey

Bengtsson¹

1981

Acta Ophthalmologica

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The present study was based on already existing clinical data concerning 599 persons born before 1907, examined during a general ophthalmic survey 1969-72 and still remaining in the same district in July 1980. At the survey 1969-72, 19 out of 1057 persons had manifest glaucoma, 14 were already treated for ocular hypertension, 54 had an IOP greater than 20.5 mmHg and 970 were considered normal. Immediately after the survey, 17 patients were treated for manifest glaucoma and 19 for ocular hypertension. During the following 9 years treated persons were lost to a greater extent (64%) than untreated persons (43%). In July 1980 only 6 persons treated for manifest glaucoma since the survey remained, and 3 of them were socially blind. One out of 7 treated and 2 out of 28 untreated persons with ocular hypertension at the survey had developed visual field defects 9 years later. Manifest glaucomas, often advanced cases, were also detected in 9 persons considered normal at the survey. 5 out of 12 persons with manifest glaucoma detected after the survey had an IOP less than 20.5 mmHg at detection. The visual capacity of persons still remaining in the district 1980 was largely independent of all efforts to prevent blindness from glaucoma in the present population.

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Section: Discussionsupporting

confidence: 92%

Manifest Glaucoma in the Aged I: Occurrence Nine Years After a Population Survey

Bengtsson¹

1981

Acta Ophthalmologica

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“…67 Furthermore, optic disc haemorrhages may represent areas of perivascular barrier dysfunction at the edge of the optic nerve head in glaucoma. 68 Potentially, breakdown of the blood-retinal barrier may alter the extracellular mileu and permit the extravasation of circulating peptides, such as the potent vasoconstrictor endothelin-1. 69 This may explain why patients with increased plasma levels of endothelin-1 are at greater risk of progression.…”

Section: Discussionmentioning

confidence: 99%

Gap junction protein connexin43 (GJA1) in the human glaucomatous optic nerve head and retina

Kerr

Johnson

Green

et al. 2011

Journal of Clinical Neuroscience

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“…A number of population-based studies [1][2][3][4][5][6] have been published on the prevalence of disc haemorrhages (DHs), which reportedly precede both retinal nerve fibre loss and visual field damage in glaucoma. [7][8][9][10][11] In Japan, however, no population-based study has been carried out on the prevalence of DHs, although two groups of investigators 12,13 have reported the prevalence of DHs among large numbers of self-participating subjects in health-care programmes.…”

Section: Introductionmentioning

confidence: 99%

Population-based prevalence of optic disc haemorrhages in elderly Japanese

Tomidokoro

Iwase

Araie

et al. 2008

Eye

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Purpose To estimate the population-based prevalence of disc haemorrhages (DHs) in an elderly Japanese population and evaluate related factors including optic disc morphology. Patients and methods Colour fundus photographs were taken during the screening examination of the Tajimi Study, during which 3021 of 3870 eligible residents of the city aged 40 years or older were screened (response rate, 78.1%). All fundus photographs were graded by one masked examiner to determine the presence of DHs. Results Good quality fundus photographs were available for both eyes of 2761 subjects. DHs were found in at least one eye of 34 subjects (1.2%; 95% confidence interval (CI) 0.8-1.6%). The prevalence was 14.0% (95% CI, 8.0-19.9%), 9.7% (2.9-16.6%), and 0.4% (0.1-0.6%) in subjects with definitive glaucoma, glaucoma suspects, and subjects without glaucoma, respectively. Logistic regression analyses indicated that DHs were associated with glaucoma (Po0.001), glaucoma suspects (Po0.001), and older age (P ¼ 0.032). No Heidelberg Retina Tomograph parameters differed between subjects with and without DHs. Conclusions The prevalence of DHs was 1.2% in an elderly Japanese population, which was similar to other population studies. In addition to glaucoma, older age was associated with higher prevalence of DHs.

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Disc Haemorrhage and Glaucoma

Cited by 129 publications

References 10 publications

Manifest Glaucoma in the Aged I: Occurrence Nine Years After a Population Survey

Manifest Glaucoma in the Aged I: Occurrence Nine Years After a Population Survey

Gap junction protein connexin43 (GJA1) in the human glaucomatous optic nerve head and retina

Population-based prevalence of optic disc haemorrhages in elderly Japanese

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