Healthcare informatics research is a newly emerging interdisciplinary science to pursue the evidence-based information and knowledge applicable to enhance care management decisions and practices (Wan, 2006). The ultimate goal of this research is to guide administrative and clinical pursuits for excellence and to optimize health organizations' effectiveness and efficiency. Historically speaking, several scientific disciplines have established their research paradigms by employing a multidisciplinary perspective to improve health and health care. Their interdisciplinary approaches to personal and population health may include: 1) human ecology, a study of human adaptation and lifestyle in varying geospatial settings; 2) health demography, a study of vital events such as fertility, morbidity, mortality, and disability; 3) medical sociology, a study of synergism of social and environmental factors influencing health and illness of the population; 4) clinical epidemiology, a study of patterns and trends of morbidity and mortality associated with interventions and outcomes of care; 5) health economics, a study of consumption of health services, efficiency, and financial arrangements influencing the delivery of health care services; 6) health psychology, a study of behavioral-related factors such as attitude, perception, motivation, and preference for health related actions; 7) preventive medicine, a study of preventive strategies and interventions in the promotion of community and population health; 8) data science, in performing warehousing, mining, and statistical modeling of multilevel data to capture administrative and self-report data, to convert raw data into meaningful information, and to analyze data and formulate predictive analytics for health care improvement; and 9) health information science and management, a web of information networks enabling transformation and dissemination of systematic review and meta-analysis of results from clinical trial studies.We have observed four emerging trends in healthcare informatics research around the globe (Wan, 2010;Kroneman et al, 2016;Jacobsen, 2008). First, healthcare researchers advocate the deployment of translational (converting basic science and knowledge into clinical practice for human health), transformational (directing a paradigm shift from a complex to parsimonious application of care management plans), and transdisciplinary investigations (integrating multi-factorial approaches into a coherent state of knowledge for enhancing behavioral and societal changes). Second, the technological innovations have driven the directions of knowledge management and development, information sharing and dissemination, and clinical care technology application. The availability of high-performance computers speeds up data processing and analytical capabilities of investigators. Third, collaborative opportunities among scientists and practitioners have shaped new research ventures in tackling common and special problems in the delivery of health care systems. There are exce...