Background: Low birth weight infants are born weighing less than 2500 grams. The chance of life increases with the advancement of technology through intensive care in the perinatology ward. High medical needs during infant care, duration of care, and lack of knowledge about the condition of the infant are factors that causes stress on mothers to bring the infant home. Mother may feel incompetence in caring for the infant at home. Greater stress occurs among mothers who are lack of proper coping skills. Objective: This study aimed to appraise mothers' coping strategies for dealing with stress related to the discharge preparations of a low birth weight (LBW) infant. Sixty mothers of LBW infants hospitalized in a perinatology ward participated in this descriptive-correlational study. They were selected using a convenience sampling method. Data were collected using a structured questionnaire of the Stress and Coping Strategies Scale, and the questionnaire was tested for validity and reliability (Cronbach's alpha: 0.72). Descriptive and inferential statistics, including the Pearson's correlation test, were applied to analyze the data using SPSS. Results: Most mothers (86%) used coping strategies focused on emotions, and 78% reported using ones that focus on solving problems. There was a significant correlation among the infant's length of hospitalization (p. 0.024) and history of hyperbilirubinemia (p. 0.007) with a mother's coping strategy. We also found a strong significant correlation between mothers' stress and coping strategies (r. −0.641; p. < 0.001). Conclusion: This study indicate that stress scores are significantly associated with coping strategies: the higher the score, the lower the mother's coping ability. Developing a maternal coping strategy that focuses on problem solving will increase mother's confidence in preparing for the discharge of LBW infants from perinatology ward and able to care for the baby at home. We recommend that nurses help mothers develop coping strategies with a focus on problem solving through family involvement and educational care for LBW infants.