Discitis and sacroiliitis diagnosed 15years after iatrogenic Mycobacterium xenopi inoculation

Salmon, Jean-Hugues; Direz, Guillaume; Ziza, Jean-Marc; Desplaces, Nicole; Brochot, P.; Eschard, Jean-Paul

doi:10.1016/j.jbspin.2012.02.001

Cited by 9 publications

(4 citation statements)

References 12 publications

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“…Nontuberculous mycobacteria (NTM) comprise a large group of organisms widely present in the environment and considered opportunistic pathogens causing pulmonary, soft tissue, lymphatic, and disseminated infections (2). Species such as M. abcsessus, M. xenopi, and M. chimaera have also been involved in nosocomial outbreaks (3)(4)(5)(6). An accurate identification (ID) of NTM is, then, important for epidemiological and public health and for therapeutic reasons.…”

mentioning

confidence: 99%

Comparison of Saramis 4.12 and IVD 3.0 Vitek MS Matrix-Assisted Laser Desorption Ionization–Time of Flight Mass Spectrometry for Identification of Mycobacteria from Solid and Liquid Culture Media

et al. 2017

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During the last decade, many investigators have studied matrix-assisted laser desorption ionization-time of flight mass spectrometry (MALDI-TOF MS) for identification of mycobacteria. Diverse and contradictory results indicated that optimal level for routine testing has not been reached yet. This work aimed to assess Vitek MS through two distinct versions, Saramis v4.12 RUO and the IVD v3.0, under conditions close to routine laboratory practice. Overall, 111 mycobacterial isolates were subjected to protein extraction and same spectra were matched against both databases. The IVD v3.0 database proved to be superior to Saramis v4.12 and its identification rates remarkably increased, from 67% to 94% for isolates grown on Middlebrook 7H10 solid medium and from 62% to 91% for isolates grown on mycobacterial growth indicator tube (MGIT) liquid medium. With this new version, IVD v3.0, MALDI-TOF MS might be integrated into routine clinical diagnostics, although molecular techniques remain mandatory in some cases.

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mentioning

confidence: 99%

Comparison of Saramis 4.12 and IVD 3.0 Vitek MS Matrix-Assisted Laser Desorption Ionization–Time of Flight Mass Spectrometry for Identification of Mycobacteria from Solid and Liquid Culture Media

et al. 2017

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“…M. xenopi is an emerging opportunistic pathogen and should be considered as a potential zoonotic agent [ 2 , 3 ]. Although we have no confirmed disease in the owner of the ferret, we should be aware that the onset of symptoms is insidious, and the infection may progress slowly or increase and decrease over the months or years [ 26 ]. The rates of NTM lung diseases, of which M. xenopi is one of the most common causes, increase with human age and chronic diseases as well as menopause in women [ 27 , 28 ].…”

Section: Discussionmentioning

confidence: 99%

Mycobacteriosis in a Pet Ferret (Mustela putorius furo) Caused by Mycobacterium xenopi: A Case Report on Neglected Risk of Zoonotic Transmission

Mihaljević,

Reil,

Habuš

et al. 2024

Pathogens

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Ferrets are highly susceptible to a wide range of mycobacteria, mainly M. bovis, M. avium, and M. triplex. Therefore, ferrets pose a risk of transmission of mycobacteriosis, especially zoonotically relevant tuberculosis. The aim of this study was to describe the findings of M. xenopi mycobacteriosis in a pet ferret and emphasize its zoonotic potential. A pet ferret had a history of weight loss, apathy, hyporexia, and hair loss. Abdominal ultrasound revealed splenomegaly with two solid masses and cystic lesions of the liver. Fine-needle aspiration cytology revealed numerous acid-fast bacilli in epithelioid cells, thus leading to the suspicion of mycobacterial infection. Because of its poor general condition, the ferret was euthanized. Necropsy examination revealed generalized granulomatous lymphadenitis, pneumonia, myocarditis, splenitis, and hepatitis. Histologically, in all organs, there were multifocal to coalescing areas of inflammatory infiltration composed of epithelioid macrophages, a low number of lymphocytes, and plasma cells, without necrosis nor multinucleated giant cells. Ziehl–Neelsen staining detected the presence of numerous (multibacillary) acid-fast bacteria, which were PCR-typed as M. xenopi. This is the first study showing the antimicrobial susceptibility testing of M. xenopi in veterinary medicine, describing the resistance to doxycycline. Overall, our results could facilitate further diagnosis and provide guidelines for the treatment protocols for such infections.

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“…A Pub-Med search for “Mycobacterium xenopi” plus “spinal” or “vertebral” in humans, published in English and French through August 2022 resulted in 18 unique cases of M. xenopi spine infections, dating between 1983 and 2022 ( Table 2 ). [6] , [7] , [8] , [9] , [10] , [11] , [12] , [13] , [14] , [15] , [16] , [17] , [18] , [19] , [20] , [21] , [22] , [23] We found a report with 58 spinal infection cases during an outbreak in a French Sport Clinic, but since there was no clinical data describing the cases, we did not include that paper in the review of cases. [24] .…”

Section: Discussionmentioning

confidence: 99%

Mycobacterium xenopi native vertebral osteomyelitis and discitis: Case & review of published cases

Bekina-Sreenivasan

Saleeb

Schmalzle

2023

IDCases

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Discitis and sacroiliitis diagnosed 15years after iatrogenic Mycobacterium xenopi inoculation

Cited by 9 publications

References 12 publications

Comparison of Saramis 4.12 and IVD 3.0 Vitek MS Matrix-Assisted Laser Desorption Ionization–Time of Flight Mass Spectrometry for Identification of Mycobacteria from Solid and Liquid Culture Media

Comparison of Saramis 4.12 and IVD 3.0 Vitek MS Matrix-Assisted Laser Desorption Ionization–Time of Flight Mass Spectrometry for Identification of Mycobacteria from Solid and Liquid Culture Media

Mycobacteriosis in a Pet Ferret (Mustela putorius furo) Caused by Mycobacterium xenopi: A Case Report on Neglected Risk of Zoonotic Transmission

Mycobacterium xenopi native vertebral osteomyelitis and discitis: Case & review of published cases

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