Discoidin domain receptor-1 and periostin: new players in chronic kidney disease

Abstract

The incidence and prevalence of chronic kidney disease represents an important problem for public health. In renal diseases, the main histologic alterations derive from the development of renal fibrosis which results from the loss of the balance between pro- and anti-fibrotic factors. Tyrosine kinase receptors (RTKs) and matricellular proteins (MPs) are nowadays studied as potential modulators of renal injury. RTKs regulate cell cycle, migration, metabolism and cellular differentiation. Discoidin domain receptor-1 (DDR-1) is an RTK that has been extensively studied in cancer, and lung and renal diseases. It modulates inflammatory recruitment, extracellular matrix deposition and fibrosis; in renal diseases, it appears to act independently of the underlying disease. MPs regulate cell-matrix interactions and matrix accumulation, cellular adhesion and migration, and expression of inflammatory cells. Periostin is an MP, mainly studied in bone, heart, lung and cancer. Several studies demonstrated that it mediates cell-matrix interactions, migration of inflammatory cells and development of fibrosis. Recently, it has been reported in several nephropathies. In this review, we discuss the potential pathological roles of DDR-1 and periostin focussing on the kidney in both experimental models and human diseases.

Association between periodontitis and chronic kidney disease: Systematic review and meta‐analysis

“…Moreover, most of the studies focused on unspecific markers such as CRP (Ismail et al, 2013). Therefore, more specific markers such as periostin, discoidin domain receptor 1, or unspecific novel mediators of renal fibrosis (synthesized following injury to glomerular and tubular epithelial cells), for instance, neutrophil gelatinase-associated lipocalin (NGAL), should be considered for future trials or association studies (Alfieri et al, 2015;Kavvadas, Dussaule, & Chatziantoniou, 2014).…”

Restored nitric oxide bioavailability reduces the severity of acute-to-chronic transition in a mouse model of aristolochic acid nephropathy

“…We also established for the first time that Periostin mRNA is overexpressed in AAN. This result is not surprising since, in addition of being a marker of progression of renal fibrosis, periostin has been reported to mediate renal disease through interaction with the TGF-β pathway[ 46 ]. This effect of periostin might therefore explain the similar pattern of TGF-β and Periostin mRNA expression observed throughout our protocol.…”

Promotion of Chondrosarcoma Cell Survival, Migration and Lymphangiogenesis by Periostin

“…Periostin is a 90 kDa extracellular matrix protein composed of an Emilin-like (EMI) domain and 4 repeated and conserved fasciclin 1 (FAS1) domains. Integrins αvβ3 and αvβ5, and DDR1 have been reported as its receptors (13,14). It exists normally in periosteum and mediates bone formation (15), and is often associated with inflammation and fibrosis in adult tissues (16)(17)(18).…”