2018
DOI: 10.1016/j.trci.2018.03.005
|View full text |Cite
|
Sign up to set email alerts
|

Discontinuation and nonpublication of interventional clinical trials conducted in patients with mild cognitive impairment and Alzheimer's disease

Abstract: IntroductionDiscontinuation and nonpublication of interventional clinical trials represents a waste of already scarce resources. We sought to identify the prevalence of discontinuation and nonpublication of interventional clinical trials conducted in patients afflicted by mild cognitive impairment and Alzheimer's disease.MethodsWe conducted a retrospective, cross-sectional study on mild cognitive impairment and Alzheimer's disease–based interventional clinical trials in ClinicalTrials.gov dating back to 1995. … Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2
1
1
1

Citation Types

0
20
0

Year Published

2018
2018
2024
2024

Publication Types

Select...
8

Relationship

2
6

Authors

Journals

citations
Cited by 21 publications
(20 citation statements)
references
References 17 publications
0
20
0
Order By: Relevance
“…However, further action is needed to ensure that findings of all trials are shared with the medical community in order to build a more comprehensive body of knowledge and decrease potential redundancy. 7 Publication of inconclusive or negative results ensures that all research activities, regardless of outcome, contribute to global medical knowledge and the advancement of the field.…”
Section: Resultsmentioning
confidence: 99%
“…However, further action is needed to ensure that findings of all trials are shared with the medical community in order to build a more comprehensive body of knowledge and decrease potential redundancy. 7 Publication of inconclusive or negative results ensures that all research activities, regardless of outcome, contribute to global medical knowledge and the advancement of the field.…”
Section: Resultsmentioning
confidence: 99%
“…CTs at different phases; 80% involved drug investigations. 277 Despite extensive efforts and enormous investment, only two classes of drugs, presenting mild symptomatic effects, have been introduced in clinical practice nearly two decades ago: cholinesterase blockers (rivastigmine, donepezil, galantamine) and one antagonist of glutamate NMDA receptors (i.e., memantine). A drug capable of modifying the natural trajectory of AD, thereby reducing its progression, is still lacking.…”
Section: State-of-the-art Cts In Nddsmentioning
confidence: 99%
“…One identified 2072 CTs in the database ClinicalTrials.gov: only 229 were fully published 276 . The other review included 744 CTs at different phases; 80% involved drug investigations 277 . Despite extensive efforts and enormous investment, only two classes of drugs, presenting mild symptomatic effects, have been introduced in clinical practice nearly two decades ago: cholinesterase blockers (rivastigmine, donepezil, galantamine) and one antagonist of glutamate NMDA receptors (i.e., memantine).…”
Section: State‐of‐the‐art Cts In Nddsmentioning
confidence: 99%
“…85 These improvements in trial design and interpretation will clearly benefit from an increased publication of trial data which is currently just 27% of completed trials. 86 It is projected that by 2050 there will be 150 million people suffering with dementia globally with the majority having AD. 2 Effective treatments are urgently required to alleviate the symptoms and arrest progression of the disease.…”
Section: Conclusion and Future Directionmentioning
confidence: 99%