Discontinuing Cardiopulmonary Bypass

Nguyen, Liem Thanh; Roth, David M.; Shanewise, Jack S.; Kaplan, Joel A.

doi:10.1016/b978-0-323-49798-5.00028-0

Cited by 3 publications

(2 citation statements)

References 19 publications

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“…Dobutamine is a β-1 agonist approved by the FDA in 1978 for short-term use in patients with decreased contractility caused by heart failure or cardiac surgical procedures, leading to cardiac decompensation [64,65]. In 2011, Bao et al found that dobutamine inhibits the yes-associated protein (YAP)-dependent gene transcription, which has been observed in a number of types of tumors [66][67][68][69][70].…”

Section: Dobutaminementioning

confidence: 99%

Positive Inotropic Agents in Cancer Therapy: Exploring Potential Anti-Tumor Effects

Ribeiro,

Vale

2024

Targets

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Cancer remains a significant global health challenge despite advancements in diagnosis and treatment. Traditional cancer therapies often face limitations such as toxicity and drug resistance. Drug repurposing has emerged as a promising strategy to overcome these challenges by identifying new therapeutic uses for existing drugs. This review explores the potential of repurposing positive inotropic agents, which are traditionally used in cardiovascular medicine, for cancer therapy. Positive inotropic agents, including cardiac glycosides, β-agonists, phosphodiesterase inhibitors, and calcium sensitizers have shown preclinical evidence of anti-tumor activity through various mechanisms, such as modulation of the intracellular signaling pathways, increasing cyclic adenosine monophosphate (cAMP) levels, the production of nitric oxide, and decreasing reactive oxygen species levels. Despite the absence of specific clinical trials in this area, these findings suggest a promising avenue for further research and development of combination therapies to improve cancer treatment outcomes. However, challenges such as elucidating specific anti-tumor mechanisms, identifying predictive biomarkers, and optimizing safety profiles need to be addressed to fully realize the therapeutic potential of positive inotropic agents in oncology.

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Section: Dobutaminementioning

confidence: 99%

Positive Inotropic Agents in Cancer Therapy: Exploring Potential Anti-Tumor Effects

Ribeiro,

Vale

2024

Targets

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“…[ 2 3 ] In patients undergoing corrective mitral valve surgery for MR, hypotension following separation from cardiopulmonary bypass (CPB) should alert an anesthesiologist to consider a myriad of differential diagnoses including, but not limited to, iatrogenic mitral valve stenosis, hemorrhage, ischemia, and right heart failure [ Table 1 ]. [ 4 5 6 7 ] In addition, hypotension in this setting warrants consideration of an afterload mismatch. Afterload is generally considered to be the force or load against which the LV must eject during systole.…”

Section: Introductionmentioning

confidence: 99%

Aggressive treatment of afterload mismatch to address left ventricular dysfunction after mitral valve repair: A case report

Vinsant

Holecko

Whitson

et al. 2020

Int J Crit Illn Inj Sci

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Enhanced photocatalytic activity and easy recovery of visible light active MoSe₂/BiVO₄ heterojunction immobilized on Luffa cylindrica – experimental and DFT study

Chawla

Saha

Upadhyay

et al. 2021

Environ. Sci.: Nano

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Discontinuing Cardiopulmonary Bypass

Cited by 3 publications

References 19 publications

Positive Inotropic Agents in Cancer Therapy: Exploring Potential Anti-Tumor Effects

Positive Inotropic Agents in Cancer Therapy: Exploring Potential Anti-Tumor Effects

Aggressive treatment of afterload mismatch to address left ventricular dysfunction after mitral valve repair: A case report

Enhanced photocatalytic activity and easy recovery of visible light active MoSe₂/BiVO₄ heterojunction immobilized on Luffa cylindrica – experimental and DFT study

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Discontinuing Cardiopulmonary Bypass

Cited by 3 publications

References 19 publications

Positive Inotropic Agents in Cancer Therapy: Exploring Potential Anti-Tumor Effects

Positive Inotropic Agents in Cancer Therapy: Exploring Potential Anti-Tumor Effects

Aggressive treatment of afterload mismatch to address left ventricular dysfunction after mitral valve repair: A case report

Enhanced photocatalytic activity and easy recovery of visible light active MoSe2/BiVO4 heterojunction immobilized on Luffa cylindrica – experimental and DFT study

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Product

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About

Enhanced photocatalytic activity and easy recovery of visible light active MoSe₂/BiVO₄ heterojunction immobilized on Luffa cylindrica – experimental and DFT study