Discontinuous isoperibolic thermal analysis (DITA) (applied to organic components)

Abstract

Abstract. The development of the Discontinuous lsoperibolic Thermal Analysis (AITA) aims at setting up a new phase diagram investigation technique efficient in the case of organic component systems. A heterogeneous system (with at least one liquid phase) is kept in isoperibolic conditions and submitted to discontinuous composition shifts by successive additions of a thermostated solvent (or solution). It results in perturbations of the equilibrium state and then physical phenomena which bring the system back to the equilibrium. The phenomena resulting fkom the addition of liquid (dissolution, dilution.. .) imply enthalpy changes which cause temperature variations of the system. An adapted exploitation of the temperature versus time signals leads to the determination of the topology of the corresponding phase diagram.

Thermodynamic Modeling for Efficient Cocrystal Formation

“…In general, CCs are prepared by grinding, − crystallization from melt, , or crystallization from solution. − At the industrial scale, CC formation is preferably performed by crystallization from solution. ,, Specifically for the latter, effective CC formation requires knowledge of the thermodynamic phase diagram. , For a given system of API, CF, and solvent, this diagram provides the concentration range in which stable CCs can form. However, the experimental determination of these diagrams is time-consuming and expensive. − It is typically based on solubility measurements in a given system of API, CF, and solvent, − followed by analysis of the liquid phase, primarily using high-performance liquid chromatography (HPLC). ,, Another method uses a calorimetric technique. ,, In both cases, the solid phase also needs to be characterized, which is primarily performed using powder X-ray diffraction. ,,,,,,, …”

“…5,27,30 Another method uses a calorimetric technique. 25,31,32 In both cases, the solid phase also needs to be characterized, which is primarily performed using powder X-ray diffraction. 5,24,25,27,29,30,33,34 ter Horst et al developed a shortcut to identify the concentration range in an API/CF/solvent system in which stable CCs can be found.…”

Study of solid-liquid and solid-vapour equilibria in tenatoprazole potassium salt/solvents systems

“…[6][7][8][9] for details on the experimental conditions). This technique is of particular interest when solid phases are efflorescent as in the present study.…”