Discontinuous Tension-Controlled Transition between Collective Actuations in Active Solids

Baconnier, Paul; Shohat, Dor; Dauchot, Olivier

doi:10.1103/physrevlett.130.028201

Cited by 8 publications

(3 citation statements)

References 39 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…An intriguing avenue for further research on this system involves a deeper investigation into the deformable properties of the vortex phase, specially considering the relevance of deformable active systems for smart soft materials and their potential application in understanding biological functions. 49 Specifically, focusing on identifying possible selection mechanisms of collective modes 50,51 and exploring whether external excitation of such modes could induce a transition from a vortex to the ferromagnetic state could unveil novel insights. Another crucial aspect deserving dedicated attention is the role of defects within the observed vortex states.…”

Section: Discussionmentioning

confidence: 99%

Polar order, shear banding, and clustering in confined active matter

Canavello,

Damascena,

Cabral

et al. 2024

Soft Matter

View full text Add to dashboard Cite

show abstract

Section: Discussionmentioning

confidence: 99%

Polar order, shear banding, and clustering in confined active matter

Canavello,

Damascena,

Cabral

et al. 2024

Soft Matter

View full text Add to dashboard Cite

show abstract

“…Notably, a previous study from our lab has demonstrated that stress amplification in the form of supracellular tension and traction forces immediately after serum stimulation is critical for activation of coherent motion, when cells are plated on a soft acrylamide substrate ( 23 ). In this respect, it is worth mentioning that tension has been shown to influence the dynamic behavior of an active solid system ( 35 ). We are now investigating how mechanical forces such as traction forces, intercellular tension, as well as extensile and compressive forces affect the dynamic behavior of ±1 defect pairs after serum stimulation of quiescent HaCaT keratinocytes.…”

Section: Discussionmentioning

confidence: 99%

Topology-guided polar ordering of collective cell migration

Lång,

Blicher

et al. 2024

Sci. Adv.

View full text Add to dashboard Cite

The ability of epithelial monolayers to self-organize into a dynamic polarized state, where cells migrate in a uniform direction, is essential for tissue regeneration, development, and tumor progression. However, the mechanisms governing long-range polar ordering of motility direction in biological tissues remain unclear. Here, we investigate the self-organizing behavior of quiescent epithelial monolayers that transit to a dynamic state with long-range polar order upon growth factor exposure. We demonstrate that the heightened self-propelled activity of monolayer cells leads to formation of vortex-antivortex pairs that undergo sequential annihilation, ultimately driving the spread of long-range polar order throughout the system. A computational model, which treats the monolayer as an active elastic solid, accurately replicates this behavior, and weakening of cell-to-cell interactions impedes vortex-antivortex annihilation and polar ordering. Our findings uncover a mechanism in epithelia, where elastic solid material characteristics, activated self-propulsion, and topology-mediated guidance converge to fuel a highly efficient polar self-ordering activity.

show abstract

“…Notably, a previous study from our lab has demonstrated that stress amplification in the form of supracellular tension and traction forces immediately after serum stimulation is critical for activation of coherent motion, when cells are plated on a soft acrylamide substrate 27 . In this respect, it is worth mentioning that tension has been shown to influence the dynamic behavior of an active solid system 36 . We are currently investigating how traction forces and intercellular tension affect the dynamic behavior of 1 topological defect pairs after serum stimulation of quiescent HaCaT keratinocytes.…”

Section: Discussionmentioning

confidence: 99%

Integer topological defect annihilations drive polar ordering of epithelial monolayers

Lång

Blicher

et al. 2023

Preprint

View full text Add to dashboard Cite

The ability of epithelial monolayers to self-organize into a dynamic polarized state is essential for tissue regeneration, development, and tumor progression. However, the mechanisms governing long-range polar ordering in biological tissues remain unclear. Here we investigate the self-organizing behavior of quiescent epithelial monolayers that transit from a disordered, static state to a dynamic state with long-range polar order upon growth factor exposure. We demonstrate that the heightened self-propelled activity of monolayer cells leads to formation of ±1 topological defect pairs that subsequently undergo sequential annihilation, ultimately driving the spread of long-range polar order throughout the system. A computational model, which treats the monolayer as an active elastic solid, accurately replicates this behavior, and weakening of cell-to-cell interactions impedes defect annihilation and polar ordering. Furthermore, we have identified a set of fundamental rules that describe how topological defects can function as local organizers to spread order through the system. Lastly, we show that transient proliferation and re-annihilation of defect pairs facilitate a 180 degrees reorientation of the collective cell flow. Our study reveals a crucial role of topological defects in generating collective motion with long-range order, and provides insights into the underlying principles of active matter physics in biological systems.

show abstract

Discontinuous Tension-Controlled Transition between Collective Actuations in Active Solids

Cited by 8 publications

References 39 publications

Polar order, shear banding, and clustering in confined active matter

Polar order, shear banding, and clustering in confined active matter

Topology-guided polar ordering of collective cell migration

Integer topological defect annihilations drive polar ordering of epithelial monolayers

Contact Info

Product

Resources

About