Genetic explanations of human behavior are increasingly common. While genetic attributions for behavior are often considered relevant for assessing blameworthiness, it has not yet been established whether judgments about blameworthiness can themselves impact genetic attributions. Across six studies, participants read about individuals engaging in prosocial or antisocial behavior and rated the extent to which they believed that genetics played a role in causing the behavior. Antisocial behavior was consistently rated as less genetically influenced than prosocial behavior. This was true regardless of whether genetic explanations were explicitly provided or refuted. Mediation analyses suggested that this asymmetry may stem from people's motivating desire to hold wrongdoers responsible for their actions. These findings suggest that those who seek to study or make use of genetic explanations' influence on evaluations of (e.g., antisocial) behavior should consider whether such explanations are accepted in the first place, given the possibility of motivated causal reasoning. Attributing human behaviors and characteristics to genetic causes can influence how people perceive and evaluate those behaviors and characteristics. 1 However, the literature suggests that the effects of genetic explanations may depend, in part, on what sort of behaviors or characteristics are being explained. 2 For stigmatized health conditions, genetic attributions are consistently linked to decreased perceptions of affected individuals as blameworthy for their disease or disability. 3-5 That is, conceptualizing conditions like obesity and mental disorders as stemming from genetic and other biological causes can reduce the extent to which individuals are held responsible for them. 3-5 This may be because attributing a Users may view, print, copy, and download text and data-mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use: