Discordance Between Glucose Levels Measured in Interstitial Fluid vs in Venous Plasma After Oral Glucose Administration: A Post-Hoc Analysis From the Randomised Controlled PRE-D Trial

Færch, Kristine; Amadid, Hanan; Bruhn, Lea; Clemmensen, Kim Katrine Bjerring; Hulmán, Ádám; Ried‐Larsen, Mathias; Blond, Martin B.; Jørgensen, Marit Eika; Vistisen, Dorte

doi:10.3389/fendo.2021.753810

Cited by 9 publications

(7 citation statements)

References 23 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…A diffusion time delay of 5-15 min was observed by different types of optical spectroscopies when 50-75 g of glucose was taken orally in an oral glucose tolerance test (OGTT; Kottmann et al, 2016;Huang et al, 2003;Pleitez et al, 2013). A variation in the lag time is associated with the rate of glucose diffusion, the magnitude of concentration difference in various tissues, blood flow, blood vessel permeability to glucose, and acute changes in the release of insulin and glucagon (Faerch et al, 2021). However, the lag time we obtained in the OMTT is higher than that of the OGTT (∼ 15 min vs. ∼ 45 min).…”

Section: In Vivo Measurementmentioning

confidence: 60%

Non-invasive blood sugar detection by cost-effective capacitance spectroscopy

Rassel

Kaysir

Aloraynan

et al. 2023

J. Sens. Sens. Syst.

View full text Add to dashboard Cite

Abstract. Capacitance spectroscopy is a promising technique for detecting small changes in electrical properties of human blood such as conductivity, permittivity, capacitance, and dielectric constant due to the change of glucose concentration. We studied the capacitance of tissue-mimicking phantoms and the human body, in vitro and in vivo, for detecting blood sugar levels non-invasively by a simple and cost-effective setup. We found that, in tissue-mimicking phantoms, capacitance decreased ∼19 % for glucose concentration increases of 85 % with a correlation coefficient of R2=0.96. In the oral meal tolerance test (OMTT), the body capacitance increased less than 9 % for a 50 % increase in blood sugar level, and it followed the invasive reference with a lag time of ∼25–45 min and semi-invasive reference with a nominal time delay. This lag time is associated with the food digestion time and the diffusion time for the glucose to reach interstitial fluid from blood vessels. We also studied different types of metal pads made of copper, gold-coated copper, and aluminum with various sizes for system optimization. Considering the simplicity, low cost, easy operation, and moderate performance, this capacitive spectroscopy could potentially be a promising technique of detecting blood sugar levels and could be incorporated into other blood sugar detection techniques to reinforce the overall performance.

show abstract

Section: In Vivo Measurementmentioning

confidence: 60%

Non-invasive blood sugar detection by cost-effective capacitance spectroscopy

Rassel

Kaysir

Aloraynan

et al. 2023

J. Sens. Sens. Syst.

View full text Add to dashboard Cite

show abstract

“…Indeed, our results showed that the 20/20% consistency decreased from 95.00% on day 1 to 85.71% on 14, and the MARD% increased from 8.73 2.65% on day 1 to 11.86 ± 3.14% on day 14, which was the same as other CGMs and should be further improved. Previous studies suggested CGM might not be a suitable tool for assessing glucose in prediabetes [24]. However, our study did not focus on the high-risk patients.…”

Section: Discussionmentioning

confidence: 92%

Evaluation of the performance and usability of a novel continuous glucose monitoring system

Yan

Guan

et al. 2022

Int J Diabetes Dev Ctries

View full text Add to dashboard Cite

Background Continuous glucose monitoring (CGM) can help manage diabetes mellitus (DM) and prevent hypoglycemia. This study aimed to evaluate the performance and usability of a novel SiJoy GS1 CGM system. Methods This multicenter trial enrolled participants with DM. Based on the comparison of glucose values measured by SiJoy GS1 CGM and venous blood glucose test, the 20/20% consistency and mean absolute relative difference (MARD%) were calculated, as well as Clarke and consensus error grid analysis. Product usability was evaluated by questionnaire completed by participants. Any occurrence of adverse events (AE) was documented. Results Seventy participants were included in the study. The mean age of participants was 41.5 ± 13.2 years, among which 29 (42.0%) were male, with the DM course of 8.6 ± 7.5 years. A total of 39 (56.5%) of them had type 1 DM, 24 (34.8%) had type 2 DM, and 6 (8.7%) were others for DM. The 20/20% consistency achieved 91.82%, which was higher than the target 65%. The percentage of A + B zones of Clarke and consensus error grid was 99.22% and 99.90%, respectively. The MARD value was 8.83% ± 4.03%. The mean score of usability questionnaire was 86.59 ± 5.17 out of 90. AE were observed in only one participant (mild fever), and no severe AEs occurred. Conclusions The SiJoy GS1 CGM system achieved satisfactory performance and usability. No severe AEs occurred and mild AE was reported in only one case.

show abstract

“…For example, the glucose management indicator-based on the average glucose from CGM readings-has been used as a surrogate for HbA1c, but it overestimates measured HbA1c in people without diabetes [107]. In addition, Faerch et al reported discordance between plasma glucose and CGM during an OGTT in adults with prediabetes [108].…”

Section: Can We Use Continuous Glucose Monitoring To Diagnose Prediab...mentioning

confidence: 99%

“…In addition, Færch et al. reported discordance between plasma glucose and CGM during an OGTT in adults with prediabetes [108].…”

Section: Questionsmentioning

confidence: 99%

Reframing prediabetes: A call for better risk stratification and intervention

Kim

2024

J Intern Med

View full text Add to dashboard Cite

Prediabetes is an intermediate state of glucose homeostasis whereby plasma glucose concentrations are above normal but below the threshold of diagnosis for diabetes. Over the last several decades, criteria for prediabetes have changed as the cut points for normal glucose concentration and diagnosis of diabetes have shifted. Global consensus does not exist for prediabetes criteria; as a result, the clinical course and risk for type 2 diabetes vary. At present, we can identify individuals with prediabetes based on three glycemic tests (hemoglobin A1c, fasting plasma glucose, and 2‐h plasma glucose during an oral glucose tolerance test). The majority of individuals diagnosed with prediabetes meet only one of these criteria. Meeting one, two, or all glycemic criteria changes risk for type 2 diabetes, but this information is not widely known and does not currently guide intervention strategies for individuals with prediabetes. This review summarizes current epidemiology, prognosis, and intervention strategies for individuals diagnosed with prediabetes and suggests a call for more precise risk stratification of individuals with prediabetes as elevated (one prediabetes criterion), high risk (two prediabetes criteria), and very high risk (three prediabetes criteria). In addition, the roles of oral glucose tolerance testing and continuous glucose monitoring in the diagnostic criteria for prediabetes need reassessment. Finally, we must reframe our goals for prediabetes and prioritize intensive interventions for those at high and very high risk for type 2 diabetes.

show abstract

Discordance Between Glucose Levels Measured in Interstitial Fluid vs in Venous Plasma After Oral Glucose Administration: A Post-Hoc Analysis From the Randomised Controlled PRE-D Trial

Cited by 9 publications

References 23 publications

Non-invasive blood sugar detection by cost-effective capacitance spectroscopy

Non-invasive blood sugar detection by cost-effective capacitance spectroscopy

Evaluation of the performance and usability of a novel continuous glucose monitoring system

Reframing prediabetes: A call for better risk stratification and intervention

Contact Info

Product

Resources

About