Discordance between lipid markers used for predicting cardiovascular risk in patients with type 2 diabetes

Efficacy and safety of alirocumab among individuals with diabetes mellitus and atherosclerotic cardiovascular disease in the ODYSSEY phase 3 trials

“…The reductions in non‐HDL‐C and apoB observed with alirocumab in the present analysis may be particularly relevant for this population of individuals with both DM and ASCVD as these lipid parameters are considered to provide a better estimate of cardiovascular risk than LDL‐C among individuals with DM, because they more closely reflect the true number of atherogenic particles compared with LDL‐C 37, 38. Alirocumab also produced significant reductions in Lp(a), which has been proposed to be an independent cardiovascular risk factor; however, other commonly used lipid‐lowering strategies such as statins or ezetimibe have little or no effect on Lp(a) 39.…”

“…Injection-site reactions were reported by 5.0% and 2.7% of alirocumab-and placebo-treated patients in the pool of placebo-controlled studies, and by 2.5% and 0.8% of alirocumab and ezetimibe recipients in the pool of ezetimibe-controlled studies; these events were mostly mild and rarely led to treatment discontinuation ( Table 2). parameters are considered to provide a better estimate of cardiovascular risk than LDL-C among individuals with DM, because they more closely reflect the true number of atherogenic particles compared with LDL-C. 37,38 Alirocumab also produced significant reductions in Lp(a), which has been proposed to be an independent cardiovascular risk factor; however, other commonly used lipid-lowering strategies such as statins or ezetimibe have little or no effect on Lp(a). 39 The Although statins have been shown consistently to reduce cardiovascular events, statin use is associated with a small but significant increased risk of developing Type 2 DM.…”

Serum uric acid to creatinine ratio correlates with β‐cell function in type 2 diabetes

“…β‐cell dysfunction is the key pathogenesis of type 2 diabetes mellitus (T2DM). Many factors contribute to the increased risk of T2DM in addition to β‐cell dysfunction, including age, family history, hyperlipidemia, and so on . In recent years, evidence indicated that high serum uric acid (SUA) was a strong and independent risk factor for diabetes .…”

Relationship between Discordance of Low-Density Lipoprotein and Non-High-Density Lipoprotein Cholesterol and Risk Stratification in Acute Myocardial Infarction

“…4 It was suggested that the LDL-C alone may give a false sense of security with one fifth of the subjects still having high cardiovascular risk, despite having normal LDL-C levels. 19 Studies evaluating the impact of discordance of LDL-C and NHDL-C on coronary heart disease prognosis are limited and to the best of our knowledge, this is the first study to investigate the association between discordance of LDL-C and NHDL-C and widely used prognostic risk scores in MI patients.…”