Discordance for placental mesenchymal dysplasia in a monochorionic diamniotic twin pregnancy: A case report

Gheysen, Willem; Strybol, David; Moerman, Philippe; Steylemans, An; Corveleyn, Anniek; Catte, Luc De; Couck, Isabel; Lewi, Liesbeth

doi:10.1002/ccr3.1662

Cited by 10 publications

(6 citation statements)

References 7 publications

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“…The combination of PMD with a normal placenta in a twin pregnancy is also very rare. Cases of dichorionic or monochorionic twin pregnancies associating 1 normal placenta and 1 placenta with PMD features have been reported (5,15,16). Although the association of p57-discordant villi (similar to PMD findings) and CHM are sometimes encountered on p57 immunostaining performed on first trimester products of conception (17), second or third trimester twin pregnancies similar to the present case featuring both PMD and CHM have only been described twice (2,8).…”

Section: Discussionmentioning

confidence: 52%

Association of Placental Mesenchymal Dysplasia With a Live Female Fetus and Complete Hydatidiform Mole: Report of a Challenging Case Confirmed by Molecular Genotyping Analysis

Hamard

Heitzmann

Ceccaldi

et al. 2021

International Journal of Gynecological Pathology

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Placental mesenchymal dysplasia (PMD) and complete hydatidiform mole (CHM) with a coexisting fetus are 2 rare placental abnormalities characterized by lacunar placenta and presence of an embryo on ultrasound examination. We report the case of a 34-yr-old woman referred at 32.6 weeks of gestation because of a multicystic placenta. A caesarean section was performed at 39.1 weeks of gestation giving birth to a 2905 g normal female infant. Pathological examination revealed macroscopic and microscopic morphological, and immunohistological features of PMD in the main placenta, and features of CHM in a separate placental mass. Fluorescent in situ hybridization and molecular genotyping analyses showed diandric diploidy in the CHM component and androgenetic/biparental mosaicism in the PMD component, confirming the association of PMD and CHM with a live infant. There was no progression to gestational trophoblastic neoplasia during follow-up for the mother, or any sign of Beckwith-Wiedemann syndrome or hepatic tumor in the child.

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Section: Discussionmentioning

confidence: 52%

Association of Placental Mesenchymal Dysplasia With a Live Female Fetus and Complete Hydatidiform Mole: Report of a Challenging Case Confirmed by Molecular Genotyping Analysis

Hamard

Heitzmann

Ceccaldi

et al. 2021

International Journal of Gynecological Pathology

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“…No trophoblastic hyperplasia was seen. In the stem villi, the trophoblastic cells were p57 positive, whereas the stromal fibroblasts were p57 negative, thus confirming discordancy for placental mesenchymal dysplasia in a monochorionic placenta [59].…”

Section: Pmd and Multiple Gestationsmentioning

confidence: 77%

Placental Mesenchymal Dysplasia; Current Understanding of the Sonographic, Histologic, and Molecular Findings of a Rare and Challengin Disorder

Lazebnik

2020

JGWH

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“…The membranes, chorionic mesoderm, and vessels are diandric diploid (46 paternally chromosomes). The trophoblastic cells have normal biparental diploidy [ 16 ], but fetal aneuploidy is not excluded [ 30 ]. Biparental/androgenetic mosaicism is rarely diagnosed in humans.…”

Section: Discussionmentioning

confidence: 99%

“…Most of the reported cases of PMD are singleton pregnancies, but there are documented cases of one twin PMD placenta either from monochorionic or dichorionic twin pregnancy [ 16 , 17 , 27 ]. The newborns were both male and female, had IUGR, were delivered prematurely in 2/3 cases [ 16 , 17 , 27 ], and experienced IUFD in one case [ 27 ].…”

Section: Discussionmentioning

confidence: 99%

A Challenging Diagnosis: Placental Mesenchymal Dysplasia—Literature Review and Case Report

et al. 2022

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We describe a 22-year-old woman (2-gravid) case who was referred to our clinic at 18 weeks of gestation for a placenta with vesicular lesions discovered on prenatal examination routine. An ultrasound exam at 31 weeks of gestation showed numerous vesicular lesions, which gradually augmented as the pregnancy advanced. A live normal-appearing fetus was confirmed by intrauterine growth restriction (IUGR). The maternal serum β-human chorionic gonadotropin level remained in normal ranges. At some point, a multidisciplinary medical consensus considered the termination of the pregnancy, but the patient refused to comply. At 33 weeks of gestation, preterm premature rupture of membranes (pPROM) occurred, and she spontaneously delivered a 1600 g healthy female baby with a good long-term outcome. Placental mesenchymal dysplasia (PMD) was retrospectively diagnosed after confronting the data from ultrasound, chorionic villus sampling (CVS), amniocentesis, pathological examination, and immunohistochemical stain. The lack of sufficient reports of PMD determines doctors to be cautious and reserved, approaching these cases more radically than necessary. We reviewed this disease and searched for all cases of PMD associated with healthy, live newborns.

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Discordance for placental mesenchymal dysplasia in a monochorionic diamniotic twin pregnancy: A case report

Cited by 10 publications

References 7 publications

Association of Placental Mesenchymal Dysplasia With a Live Female Fetus and Complete Hydatidiform Mole: Report of a Challenging Case Confirmed by Molecular Genotyping Analysis

Association of Placental Mesenchymal Dysplasia With a Live Female Fetus and Complete Hydatidiform Mole: Report of a Challenging Case Confirmed by Molecular Genotyping Analysis

Placental Mesenchymal Dysplasia; Current Understanding of the Sonographic, Histologic, and Molecular Findings of a Rare and Challengin Disorder

A Challenging Diagnosis: Placental Mesenchymal Dysplasia—Literature Review and Case Report

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