Discordant expression of desmoglein 2 and 3 at the mRNA and protein levels in nodular and superficial basal cell carcinoma revealed by immunohistochemistry and fluorescentin situhybridization

Abstract

Because more prominent aberrations of Dsg2/Dsg3 expression were seen at the protein than at the mRNA level in BCC, these comparative observations indicate greater importance of events at the proteome level than those at the genome level in tumour functional compartments. Different Dsg2/Dsg3 expression in sBCC and nBCC might corroborate the possibility that sBCC and nBCC are separate conditions. These results may contribute to better understanding of the biological behaviour of BCC.

NAP1L1: A Novel Human Colorectal Cancer Biomarker Derived From Animal Models of Apc Inactivation

“…This was a somewhat unexpected finding, given the increased expression of NAP1L1 mRNA in animal models and in human tissues. Such discrepancy between mRNA and protein expression has however previously been demonstrated for other cancer markers (35)(36)(37). Several processes could be responsible, such as posttranscriptional modifications, protein degradation, secretion via exocytosis or alterations in subcellular protein localization.…”

A Phase 3 Randomized Trial of Nicotinamide for Skin-Cancer Chemoprevention

“…However, interpretation was limited by small numbers of high-risk subtypes of basal-cell carcinoma (micronodular, infiltrating, and morpheic) and of poorly differentiated squamous-cell carcinomas. The characteristics of superficial basal-cell carcinomas differ from those of nodular basalcell carcinomas at the molecular level, 33 and superficial basal-cell carcinomas are proportionally more common in immunosuppressed transplant recipients, 34 which suggests that different biologic pathways underlie the pathogenesis of superficial basal-cell carcinomas and may enable them to be more readily prevented by nicotinamide.…”

Mucosal-dominant pemphigus vulgaris in a captopril-taking woman with angioedema

“…As it is postulated that DSG3 is involved in both pemphigus and BCC pathogenesis, we cannot exclude the possibility of BCC as a contact pemphigus, co-triggering factor. 5 …”