Discordant mycosis fungoides and cutaneous B-cell lymphoma: A case report and review of the literature

Concurrent Presentation of Mycosis Fungoides and Primary Cutaneous Marginal Zone LPD: Clinicopathological Study of 4 Cases and Literature Review

“…Although rarely, other cases of both B-cell and T-cell primary cutaneous lymphomas have been reported, 4–14 most of them corresponding to MF (10/11) 4–10,13 and Epstein–Barr virus–positive large B-cell lymphoproliferative disorders (4/11) 4,6,10 Nevertheless, they usually develop after MF treatment and appear at different sites of previous MF cutaneous lesions. Interestingly, we found only 5 cases presenting both lymphomas in the same cutaneous biopsy specimen (true composite lymphomas).…”

“…We add 4 cases of primary cutaneous concurrent lymphomas to the 11 previously described cases in the literature. [4][5][6][7][8][9][10][11][12][13][14][15] Altogether, MF was the primary cutaneous T-cell lymphoma (TCL) more frequent (86%), followed by PTCL-NOS (2 cases) and subcutaneous panniculitis-like T-cell lymphoma (1 case). Regarding the associated primary cutaneous B-cell lymphoma (BCL), half of the cases consisted of low-grade B-cell lymphomas, including our 4 cases; 25% were associated to Epstein-Barr virus; 1 case consisted of a methotrexate-associated lymphoproliferative disease, and 2 cases consisted of primary cutaneous diffuse large B-cell lymphoma.…”

“…4 Very few cases of concurrent B-cell and T-cell primary cutaneous lymphomas have been reported in the English literature. [4][5][6][7][8][9][10][11][12][13][14][15] We report here 4 patients presenting with lesions of both MF and primary cutaneous marginal zone lymphoproliferative disease and review the pertinent literature. †TCL and BCL in the same tissue sample.…”

“…4 Very few cases of concurrent B-cell and T-cell primary cutaneous lymphomas have been reported in the English literature. 4–15…”