Discourse plasticity in children after stroke: age at injury and lesion effects

Chapman, Sandra B.; Max, Jeffrey E.; Gamino, Jacquelyn F.; McGlothlin, Jenny H; Cliff, Starr N

doi:10.1016/s0887-8994(03)00012-2

Cited by 78 publications

(67 citation statements)

References 23 publications

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“…Similar to previous reports, 12,13,16,22 we found no lateralization effect on cognitive outcome. Contrary to the nonexistent laterality effect on outcome, we confirmed a negative influence of acute and persisting seizures on cognitive outcome.…”

Section: Neurology 82 March 4 2014supporting

confidence: 92%

“…This strengthens our finding that young age at stroke has a significant negative influence on cognitive outcome and is in line with the early vulnerability thesis, replicating findings of previous studies 11,12,[14][15][16] as well as confirming our second hypothesis. Although sex did not influence cognitive outcome, the distinctive sex imbalance in the preschool age group is of interest.…”

Section: Neurology 82 March 4 2014supporting

confidence: 92%

“…[7][8][9][10] However, younger age at stroke is associated with poorer intellectual outcome and a broader spectrum of dysfunctions across multiple neuropsychological domains. 6,[11][12][13][14][15][16][17] Further, children with combined cortical and subcortical lesions have overall poorer cognitive outcome, 16,18 and larger lesion size negatively influences cognitive and functional outcome, 4,19,20 possibly due to disruption of more neural network connections, adversely affecting functional brain organization. 21 Regarding lesion laterality, controversial reports exist concerning the effect of lesion laterality on neuropsychological outcome.…”

mentioning

confidence: 99%

“…21 Regarding lesion laterality, controversial reports exist concerning the effect of lesion laterality on neuropsychological outcome. [11][12][13]15,16,22 In addition, persistent seizures 10,22 and persistent NI such as hemiplegia/paresis or visual field deficits also negatively influence neuropsychological and functional outcome. 5,11,19 The main goal of this study was to examine the influence of age, lesion characteristics, seizures, NI, and functional outcome on cognitive outcome in a population-based group of children 2 years after an AIS occurrence.…”

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confidence: 99%

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Factors affecting cognitive outcome in early pediatric stroke

et al. 2014

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OBJECTIVE: We examined cognitive performance in children after stroke to study the influence of age at stroke, seizures, lesion characteristics, neurologic impairment (NI), and functional outcome on cognitive outcome. METHODS: This was a prospectively designed study conducted in 99 children who sustained an arterial ischemic stroke (AIS) between the age of 1 month and 16 years. All children underwent cognitive and neurologic follow-up examination sessions 2 years after the insult. Cognitive development was assessed with age-appropriate instruments. RESULTS: Although mean cognitive performance was in the lower normative range, we found poorer results in subtests measuring visuoconstructive skills, short-term memory, and processing speed. Risk factors for negative cognitive outcome were young age at stroke, seizures, combined lesion location (cortical and subcortical), as well as marked NI. CONCLUSIONS: We recommend that all children with a history of AIS undergo regularly scheduled neuropsychological assessment to ensure implementation of appropriate interventions and environmental adjustments as early as possible. Factors affecting cognitive outcome in early pediatric stroke ABSTRACT Objective: We examined cognitive performance in children after stroke to study the influence of

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Section: Neurology 82 March 4 2014supporting

confidence: 92%

Section: Neurology 82 March 4 2014supporting

confidence: 92%

mentioning

confidence: 99%

mentioning

confidence: 99%

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Factors affecting cognitive outcome in early pediatric stroke

et al. 2014

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“…There is considerable evidence that an early brain insult is associated with a broad spectrum of neuropsychological dysfunction [57,58]. In fact, the onset of stroke at a younger age predisposes to an overall worse prognosis [59][60][61], weaker cognitive performance, and is subject to lesion location [62]. Westmacott et al [62] reported that individuals who suffered a subcortical stroke (affecting the thalamus and/or basal ganglia axis) before the age of 28 days performed significantly poorer in terms of intellectual performance than older children with the same insult.…”

Section: Predictors Of Long-term Neurodevelopmen-tal Outcome Followinmentioning

confidence: 99%

Cerebral White Matter Injuries Following a Hypoxic/Ischemic Insult During the Perinatal Period: Pathophysiology, Prognostic Factors, and Future Strategy of Treatment Approach. A Minireview

Zammit

Muscat

Sani³

et al. 2015

CPD

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Recent advances in medical care have significantly improved the survival rate of neonates who suffer a hypoxic/ischemic event, before, during, or after birth. These infants are extremely vulnerable to brain injury and are at high risk of developing motor and cognitive abnormalities later on in life. The regional distribution of perinatal brain injury varies, and depends primarily on; the severity, pattern and type of insult, the metabolic status, and on the gestational age. The principal neuropathological substrate that is affected in the premature infant is cerebral white matter. The aim of this article is to reexamine the current knowledge on the ischemic pathophysiology of all cellular components that comprise the white matter, predict the consequences of the long-term neurological outcome, and analyze possible therapeutic strategies. Although oligodendrocytes have long been regarded as the hallmark of perinatal white matter injury, axons, astrocytes and microglia, all contribute to the complex pattern of brain injury that occurs in this cohort of individuals. It is hoped that a better understanding of the pathophysiology of white matter injury and its underlying prognostic factors, may lead to the development of new therapeutic strategies for such a complex and debilitating condition.

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Evidence‐Based Diagnosis of Speech, Language and Swallowing following Paediatric Stroke

Morgan

2010

Embedding Evidence‐Based Practice in Speech and Language Therapy

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Discourse plasticity in children after stroke: age at injury and lesion effects

Cited by 78 publications

References 23 publications

Factors affecting cognitive outcome in early pediatric stroke

Factors affecting cognitive outcome in early pediatric stroke

Cerebral White Matter Injuries Following a Hypoxic/Ischemic Insult During the Perinatal Period: Pathophysiology, Prognostic Factors, and Future Strategy of Treatment Approach. A Minireview

Evidence‐Based Diagnosis of Speech, Language and Swallowing following Paediatric Stroke

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