Discovering the enzyme mimetic activity of metal-organic framework (MOF) for label-free and colorimetric sensing of biomolecules

Wang, Ying; Zhu, Yingjing; Binyam, Atsebeha; Liu, Misha; Wu, Yi-nan; Li, Fengting

doi:10.1016/j.bios.2016.06.036

Cited by 185 publications

(55 citation statements)

References 33 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Since the discovery by Yan and coworkers that Fe 3 O 4 nanoparticles possess intrinsic peroxidase-like activity and show potential to replace natural peroxidase in bioassays, 14 substantial research is directed toward the development of nanomaterial catalysts that mimic functions of peroxidase, oxidase or other natural enzymes with the advantages of low cost, controlled synthesis, tunable catalytic activities, and high stability even under severe reaction conditions. Till now, a variety of nanoscale materials have been developed as the efficient enzyme alternatives [15][16][17][18][19][20][21][22][23][24][25][26][27][28][29] and their diverse applications cover from sensing, imaging, and therapeutics, to pollutant removal, water treatment and beyond. [30][31][32] Among these, much work is centered on the noble metal-based nanozymes, particularly gold, platinum, palladium, and iridium, because of their well-developed synthesis techniques, easy modication of surface, excellent catalytic activity, good bio-compatibility and so on.…”

Section: Introductionmentioning

confidence: 99%

Mimicking horseradish peroxidase and oxidase using ruthenium nanomaterials

et al. 2017

View full text Add to dashboard Cite

show abstract

Section: Introductionmentioning

confidence: 99%

Mimicking horseradish peroxidase and oxidase using ruthenium nanomaterials

et al. 2017

View full text Add to dashboard Cite

show abstract

“…More importantly, the MIL‐100(Fe) shell can selectively absorb cholesterol from several interfering substances, which was expected to be applied to detect cholesterol in serum (Figure b). In particular, Wang et al reported a label‐free sensing strategy for colorimetric detection of thrombin . As shown in Figure c, they constructed the detecting system by using aptamer as target identification unit to couple with pure Fe‐MIL‐88A.…”

Section: Applicationsmentioning

confidence: 99%

Section: Applicationsmentioning

confidence: 99%

State‐of‐the‐Art Advances and Challenges of Iron‐Based Metal Organic Frameworks from Attractive Features, Synthesis to Multifunctional Applications

Xia

Wang

Huang

et al. 2018

Small

152

View full text Add to dashboard Cite

The ORCID identification number(s) for the author(s) of this article can be found under https://doi.org/10.1002/smll.201803088.Metal organic frameworks (MOFs), as an original kind of organic-inorganic porous material, are constructed with metal centers and organic linkers via a coordination complexation reaction. Among uncountable MOF materials, iron-containing metal organic frameworks (Fe-MOFs) have excellent potential in practical applications owing to their many fascinating properties, such as diverse structure types, low toxicity, preferable stability, and tailored functionality. Here, recent research progresses of Fe-MOFs in attractive features, synthesis, and multifunctional applications are described. Fe-MOFs with porosity and tailored functionality are discussed according to the design of building blocks. Four types of synthetic methods including solvothermal, hydrothermal, microwave, and dry gel conversion synthesis are illustrated. Finally, the applications of Fe-MOFs in Li-ion batteries, sensors, gas storage, separation in gas and liquid phases, and catalysis are elucidated, focusing on the mechanism. The aim is to provide prospects for extending Fe-MOFs in more practical applications.Iron-Based Metal Organic Frameworks www.advancedsciencenews.com

show abstract

“…MOFs have many fascinating properties like miscellaneous skeletal structures, small particle sizes, large surface areas, porosity and propensity for host–guest interactions which make them promising for applications in various fields, like sensing, biosensing, gas separations, catalysis, nanomedicine, drug delivery, biomedical applications, biological activity, and several more. Recently, there have been extraordinary achievements in the disciplines of sensing, drug‐delivery control, nanomedicine and cancer therapy applications based on MOFs …”

Section: Introductionmentioning

confidence: 99%

A novel biosensor for early diagnosis of liver cancer cases using smart nano‐magnetic metal–organic framework

Sheta

El‐Sheikh

Abd-Elzaher

et al. 2019

Applied Organom Chemis

View full text Add to dashboard Cite

For the first time, alpha-fetoprotein (AFP) quantification as an early test for liver cancer diagnosis competing with other interfering analytes and factors based on a novel nano-magnetic metal-organic framework (MOF) was investigated. The novel nano-magnetic MOF was synthesized via a simple preparation method, and characterized using various techniques. The X-ray photoelectron spectrum of the nano-magnetic MOF shows Cu 2p, O 1s, N 1s and C 1s peaks that evidence the presence of these elements in the sample without any impurities. Scanning and transmission electron microscopy images show the nano-magnetic MOF with average size between 22 and 43 nm. The results of a photoluminescence study show that the nano-magnetic MOF exhibits strong emission at 418 nm after excitation at 354 nm. Moreover, a Stern-Völmer graph shows a linear calibration curve over an AFP concentration range 1.0-520 ng ml −1 with a correlation coefficient of 0.997, detection limit of 1.18 ng ml −1 and quantitation limit of 3.58 ng ml −1 .According to the marked quenching of the photoluminescence intensity of the nano-magnetic MOF using various concentrations of AFP, it was successfully used as a biosensor for AFP in serum samples collected from hepatitis patients in addition to healthy males and females. The quenching mechanism was well studied, and found to be a dynamic type. The present work offers a simple, low-cost, roomtemperature and rapid technique, being non-time-consuming, highly accurate, selective and highly sensitive compared with most published methods.

show abstract

Discovering the enzyme mimetic activity of metal-organic framework (MOF) for label-free and colorimetric sensing of biomolecules

Cited by 185 publications

References 33 publications

Mimicking horseradish peroxidase and oxidase using ruthenium nanomaterials

Mimicking horseradish peroxidase and oxidase using ruthenium nanomaterials

State‐of‐the‐Art Advances and Challenges of Iron‐Based Metal Organic Frameworks from Attractive Features, Synthesis to Multifunctional Applications

A novel biosensor for early diagnosis of liver cancer cases using smart nano‐magnetic metal–organic framework

Contact Info

Product

Resources

About