Discovering the main “reinforce kidney to strengthening Yang” active components of salt Morinda officinalis based on the spectrum-effect relationship combined with chemometric methods

Zhang, Dandan; Fan, Luodi; Yang, Nan; Li, Zhenglei; Sun, Zhimeng; Jiang, Siyi; Luo, Xinyao; Li, Huijun; Wei, Qiong; Ye, Xiaochuan

doi:10.1016/j.jpba.2021.114422

Cited by 17 publications

(11 citation statements)

References 17 publications

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“…Additionally, several other compounds in Radix Morindae officinalis have been demonstrated to be associated with kidney Yang-nourishing effects, including deacetyl asperulosidic acid, asperulosidic acid, and asperuloside (as presented in Figure 2). 32 Although the processing of Radix Morindae officinalis reduced the content of monotropein and deacetyl asperulosidic acid, it increased the levels of two other iridoid glycosides, asperulosidic acid, and asperuloside. 5,6 Additionally, the salt processing of Radix Morindae officinalis has been demonstrated to enhance the absorption and bioavailability of monotropein, 35 contributing to the increased Yang-tonifying effects of the herbal medicine.…”

Section: Discussionmentioning

confidence: 99%

Changes in Chemical Constituents and Kidney-Yang Tonifying of Traditional Herbs After Processing: A Brief Review

Truong,

Nguyen Thi,

Tran

et al. 2024

Natural Product Communications

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Background Kidney-Yang deficiency is one of the common medical syndromes in traditional medicine, characterized by symptoms such as weakness, coldness in the lower back and knees, cold, fatigue, etc. In clinical practice, Yang tonifying medicines are often used to treat patients with Kidney-Yang deficiency. Moreover, the medicinal processing method according to the principles of traditional medicine can enhance the effects on the Kidney of these herbs. This brief overview aims to gather and assess the post-processing modifications to the chemical composition and the kidney-Yang tonifying effects of specific traditional herbal remedies. Methodology Firstly, all kidney-Yang tonifying herbs were collected. Next, the selection was made based on the herbs with processing procedures specified in Circular 30/2017/TT-BYT issued by the Vietnamese Ministry of Health. All studies on the chemical composition and/or effects of processed drugs were searched in the PubMed and Google Scholar databases using the search formula: processed + scientific name of herbal medicine. Finally, among the studies on the changes in effects after processing, only studies on the tonifying Yang effect were included in this review. Results The kidney Yang-nourishing effects of the five traditional herbal medicines prescribed in Circular 30/2017/TT-BYT by the Ministry of Health of Vietnam (Radix Morindae officinalis, Cortex Eucommiae, Herba Cistanches, Semen Cuscutae, and Radix Dipsaci) have been demonstrated through several studies and summarized. From the PubMed and Google Scholar databases, 25 studies were collected for the review. Additionally, the changes in composition and content of certain active compounds in these herbal medicines have also been searched and reported. Conclusion This report provides a brief overview of the differences between chemical constituents and kidney-Yang tonifying of some traditional herbs after processing to partially contribute scientific evidence for standardizing the preparation processes and serve as an important reference for clinical practitioners of traditional medicine.

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Section: Discussionmentioning

confidence: 99%

Changes in Chemical Constituents and Kidney-Yang Tonifying of Traditional Herbs After Processing: A Brief Review

Truong,

Nguyen Thi,

Tran

et al. 2024

Natural Product Communications

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“…Different types of compounds can be detected by connecting different types of detectors (UV/diode-array detector (DAD)/evaporative light-scattering detector (ELSD)) with HPLC [23,24], and multiple types of compounds can be detected by connecting different types of detectors in series. Therefore, it is most widely used in the detection of small and large molecular compounds.…”

Section: Establishment Of Fingerprintsmentioning

confidence: 99%

Spectrum–Effect Relationships as an Effective Approach for Quality Control of Natural Products: A Review

He,

Zhang,

Yang

et al. 2023

Molecules

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As natural products with biological activity, the quality of traditional Chinese medicines (TCM) is the key to their clinical application. Fingerprints based on the types and contents of chemical components in TCM are an internationally recognized quality evaluation method but ignore the correlation between chemical components and efficacy. Through chemometric methods, the fingerprints represented by the chemical components of TCM were correlated with its pharmacodynamic activity results to obtain the spectrum–effect relationships of TCM, which can reveal the pharmacodynamic components information related to the pharmacodynamic activity and solve the limitations of segmentation of chemical components and pharmacodynamic research in TCM. In the 20th anniversary of the proposed spectrum–effect relationships, this paper reviews its research progress in the field of TCM, including the establishment of fingerprints, pharmacodynamic evaluation methods, chemometric methods and their practical applications in the field of TCM. Furthermore, the new strategy of spectrum–effect relationships research in recent years was also discussed, and the application prospects of this technology were discussed.

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“…Spectrum-effect relationship is one of the popular methods to study the active ingredients of TCM ( Li et al, 2019 ; Wu et al, 2021 ). It can effectively combine the fingerprint spectrum with the results of pharmacodynamics research through data processing and analysis methods, which solves the deficiencies of focusing on the ingredients and ignoring the pharmacological efficacy of TCM in the past ( Zheng et al, 2021 ; Zhang et al, 2022 ). Up to now, the analytical techniques, including liquid chromatography-ultraviolet detector (LC-UV) ( Li W. et al, 2020 ), liquid chromatography-evaporative light scattering detector (LC-ELSD) ( Zhang et al, 2021 ), infrared spectroscopy ( Li H. et al, 2020 ), capillary electrophoresis ( Ma et al, 2017 ), have been used to develop fingerprint of TCM.…”

Section: Introductionmentioning

confidence: 99%

Discovering the potential active ingredients of Qi-Yu-San-Long decoction for anti-oxidation, inhibition of non-small cell lung cancer based on the spectrum-effect relationship combined with chemometric methods

Huang

Li²,

Yang³

et al. 2022

Front. Pharmacol.

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Qi-Yu-San-Long decoction (QYSLD), a traditional Chinese medicine (TCM) prescription, consisting of ten types of herbal medicine which has significant clinical efficacy in the treatment of non-small cell lung cancer (NSCLC). However, the bioactive ingredients of QYSLD remain unclear, due to their “multi-ingredients” and “multi-targets” features. This study aimed to construct a spectrum-effect correlation analysis model and screen the potential active components of QYSLD. A fingerprint method based on ultra-high performance liquid chromatography-quadrupole time-of-flight mass spectrometry (UPLC-Q/TOF-MS) was developed and validated to obtain seventy common peaks of ten batches of QYSLD. The results of methodological evaluation, including precision, repeatability and stability, were less than 8.19%. In terms of linearity, eleven common components did not reach the linear standard (R2 < 0.99), they were removed before spectrum-effect relationship analysis. After treated with ten batches of QYSLD, the results of DPPH and FRAP assays ranged from 1.59 to 5.50 mg mL−1 and 143.83–873.83 μmol L−1, respectively. Meanwhile, the cell viabilities of A549 cells treated with QYSLD samples ranged from 21.73% to 85.71%. The relative healing rates ranged from 21.50% to 44.46%. The number of migrated and invaded cells ranged from 12.00 to 68.67 and 7.67 to 27.00, respectively. Then, the potential active components of QYSLD were screened through spectrum-effect relationship constructed by grey correlation analysis (GRA), partial least squares regression (PLSR) and backpropagation neural network (BP-ANN). The results were as follow: 1) eight ingredients of QYSLD were relevant to DPPH free radical scavenging ability; 2) nine ingredients were relevant to FRAP; 3) six ingredients were relevant to inhibit the proliferation ability of A549 cells; 4) twenty-two ingredients were relevant to inhibit the horizontal migration ability; 5) five ingredients were relevant to inhibit the vertical migration ability; 6) twelve ingredients were relevant to inhibit the invasion ability. Confirmatory experiments showed that compared with the unscreened ingredients, the potential active ingredients screened by the spectrum-effect relationship had better antioxidant and anti-NSCLC effects. In general, this study found the potential active ingredients in QYSLD. Meanwhile, the established method provided a valuable reference model for the potential active ingredients of TCM.

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Discovering the main “reinforce kidney to strengthening Yang” active components of salt Morinda officinalis based on the spectrum-effect relationship combined with chemometric methods

Cited by 17 publications

References 17 publications

Changes in Chemical Constituents and Kidney-Yang Tonifying of Traditional Herbs After Processing: A Brief Review

Changes in Chemical Constituents and Kidney-Yang Tonifying of Traditional Herbs After Processing: A Brief Review

Spectrum–Effect Relationships as an Effective Approach for Quality Control of Natural Products: A Review

Discovering the potential active ingredients of Qi-Yu-San-Long decoction for anti-oxidation, inhibition of non-small cell lung cancer based on the spectrum-effect relationship combined with chemometric methods

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