Abstract:A Tripterygium wilfordii endophyte, Streptomyces sp. CB04723, was shown to produce an unusually
highly reduced cytotoxic
cinnamoyl lipid, tripmycin A (1). Structure–activity
relationship studies revealed that both the cinnamyl moiety and the
saturated fatty acid side chain are indispensable to the over 400-fold
cytotoxicity improvement of 1 against the triple-negative
breast cancer cell line MDA-MB-231 compared to 5-(2-methylphenyl)-4-pentenoic
acid (2). Bioinformatical analysis, gene inactivation,
and overexp… Show more
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