Discovery and development of botanical natural products and their analogues as therapeutics for ovarian cancer

Mize, Brittney K.; Salvi, Amrita; Ren, Yulin; Burdette, Joanna E.; Fuchs, James R.

doi:10.1039/d2np00091a

Cited by 7 publications

(3 citation statements)

References 110 publications

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“…Geniposide has obvious advantages in the treatment of osteoporosis, such as high biological activity and multiple therapeutic mechanisms [ 127 , 129 ]. It is precisely based on these advantages of natural products that it has become the most common choice for the development of new drugs against osteoporosis [ 136 ]. Both clinical and basic experiments have shown that natural products have enormous to exert anti-osteoporosis effects.…”

Section: Discussionmentioning

confidence: 99%

Prevention and treatment of osteoporosis with natural products: Regulatory mechanism based on cell ferroptosis

Yang,

Jiang,

Qian

et al. 2023

J Orthop Surg Res

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Context With the development of society, the number of patients with osteoporosis is increasing. The prevention and control of osteoporosis has become a serious and urgent issue. With the continuous progress of biomedical research, ferroptosis has attracted increased attention. However, the pathophysiology and mechanisms of ferroptosis and osteoporosis still need further study. Natural products are widely used in East Asian countries for osteoporosis prevention and treatment. Objective In this paper, we will discuss the basic mechanisms of ferroptosis, the relationship between ferroptosis and osteoclasts and osteoblasts, and in vitro and in vivo studies of natural products to prevent osteoporosis by interfering with ferroptosis. Methods This article takes ferroptosis, natural products, osteoporosis, osteoblasts and osteoclast as key words. Retrieve literature from 2012 to 2023 indexed in databases such as PubMed Central, PubMed, Web of Science, Scopus and ISI. Results Ferroptosis has many regulatory mechanisms, including the system XC -/GSH/GPX4, p62/Keap1/Nrf2, FSP1/NAD (P) H/CoQ10, P53/SAT1/ALOX15 axes etc. Interestingly, we found that natural products, such as Artemisinin, Biochanin A and Quercetin, can play a role in treating osteoporosis by promoting ferroptosis of osteoclast and inhibiting ferroptosis of osteoblasts. Conclusions Natural products have great potential to regulate OBs and OCs by mediating ferroptosis to prevent and treat osteoporosis, and it is worthwhile to explore and discover more natural products that can prevent and treat osteoporosis.

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Section: Discussionmentioning

confidence: 99%

Prevention and treatment of osteoporosis with natural products: Regulatory mechanism based on cell ferroptosis

Yang,

Jiang,

Qian

et al. 2023

J Orthop Surg Res

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“…Moreover, a recent review provides a summary of the primary mechanisms of action through which natural products cause anti-ovarian cancer effects, including cytotoxic effects, damage due to reactive oxygen species (ROS), cell cycle arrest, induction of autophagic cell death, promotion of DNA damage response, etc. [ 29 ]. More details of the basis to investigate the efficacy of these natural products on POF can be found in our Table 1 .…”

Section: Introductionmentioning

confidence: 99%

Efficacy of natural products on premature ovarian failure: a systematic review and meta-analysis of preclinical studies

Hu,

Zhang,

Xin

et al. 2024

J Ovarian Res

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Objective This study aims to investigate the effects of natural products on animal models of premature ovarian failure (POF). Methods We conducted comprehensive literature searches and identified relevant studies that examined the protective effects of natural products on experimental POF. We extracted quantitative data on various aspects such as follicular development, ovarian function, physical indicators, oxidative stress markers, inflammatory factors, and protein changes. The data was analyzed using random-effects meta-analyses, calculating pooled standardized mean differences and 95% confidence intervals. Heterogeneity was assessed using the I2 statistic, and bias was estimated using the SYRCLE tool. Results Among the 879 reviewed records, 25 articles met our inclusion criteria. These findings demonstrate that treatment with different phytochemicals and marine natural products (flavonoids, phenols, peptides, and alkaloids, etc.) significantly improved various aspects of ovarian function compared to control groups. The treatment led to an increase in follicle count at different stages, elevated levels of key hormones, and a decrease in atretic follicles and hormone levels associated with POF. This therapy also reduced oxidative stress (specifically polyphenols, resveratrol) and apoptotic cell death (particularly flavonoids, chrysin) in ovarian granulosa cells, although it showed no significant impact on inflammatory responses. The certainty of evidence supporting these findings ranged from low to moderate. Conclusions Phytochemicals and marine natural product therapy (explicitly flavonoids, phenols, peptides, and alkaloids) has shown potential in enhancing folliculogenesis and improving ovarian function in animal models of POF. These findings provide promising strategies to protect ovarian reserve and reproductive health. Targeting oxidative stress and apoptosis pathways may be the underlying mechanism.

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“…Ovarian cancer, a predominant gynecologic tumor originating from the ovary, uterus, and related tissues, represents the acknowledged 'king of gynecological cancers' with the highest mortality, lowest cure rate, and greatest recurrence rate among its counterparts [1,2]. A survey conducted by the American Cancer Society forecasts nearly 20,000 fresh incidents of ovarian cancer are projected to occur in the United States in 2022, accompanied by over 12,000 fatalities [3].…”

Section: Introductionmentioning

confidence: 99%

Chelerythrine induces apoptosis and ferroptosis through Nrf2 in ovarian cancer cells

Jia Zhou,

Yuchen Wang,

Yangxin Fu

et al. 2024

Cell Mol Biol (Noisy-le-grand)

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Ovarian cancer is a prevalent malignancy in the female reproductive system, representing a significantly fatal and incurable tumor. Chelerythrine (CHE), a natural benzopyridine alkaloid, has demonstrated a broad spectrum of anticancer activities. Nevertheless, the ovarian cancer inhibitory impact of CHE remains unclear. In this study, we investigated the cytotoxic mechanism and potential targets of CHE on in vitro cultures of A2780 and SKOV3 cells derived from ovarian cancer. Additionally, in vivo experiments were conducted to confirm the suppressive impact of CHE on tumor growth in nude mice. The findings revealed that CHE impeded the growth of A2780 and SKOV3 cells in a concentration-time-dependent manner and significantly suppressed the development of tumors in nude mice. CHE elevated the level of oxidative stress in tumor cells, prompted cell cycle halt in the S phase, and increased their mitochondrial membrane potential. Western blotting results demonstrated that CHE could modulate the expression of proteins associated with apoptotic and ferroptosis processes in A2780 and SKOV3 cells. Nrf2 was verified to be an upstream key target mediating the inhibitory impact of CHE on ovarian cancer cells. In summary, CHE exerts its anti-cancer effects on ovarian cancer by modulating Nrf2, inhibiting cellular proliferation, and promoting apoptosis and ferroptosis.

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Discovery and development of botanical natural products and their analogues as therapeutics for ovarian cancer

Abstract: This review highlights botanical natural products with activity against ovarian cancer and key drug development considerations for their advancement.

Cited by 7 publications

References 110 publications

Prevention and treatment of osteoporosis with natural products: Regulatory mechanism based on cell ferroptosis

Prevention and treatment of osteoporosis with natural products: Regulatory mechanism based on cell ferroptosis

Efficacy of natural products on premature ovarian failure: a systematic review and meta-analysis of preclinical studies

Chelerythrine induces apoptosis and ferroptosis through Nrf2 in ovarian cancer cells

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