Discovery and development of macrocyclic peptide modulators of the cannabinoid 2 receptor
Natasa Tomasevic,
Fabiola Susanna Emser,
Jasmin Gattringer
et al.
Abstract:The cannabinoid type 2 receptor (CB2R), a G protein-coupled receptor (GPCR), is an important regulator of immune cell function and a promising target for to treat chronic inflammation and fibrosis. While CB2R is typically targeted by small organic molecules, including endo-, phyto- and synthetic cannabinoids, peptides may offer a different interaction space, owing to their larger size and greater contact area they facilitate differential interactions with a specific receptor target. Here we explore plant-deriv… Show more
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