Discovery and functional mechanism of novel dipeptidyl peptidase Ⅳ inhibitory peptides from Chinese traditional fermented fish (Chouguiyu)

Yang, Daqiao; Li, Chunsheng; Li, Laihao; Wang, Yueqi; Chen, Shengjun; Zhao, Yao; Hu, Xiao; Hui, Rutai

doi:10.1016/j.crfs.2022.09.025

Cited by 7 publications

(3 citation statements)

References 45 publications

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“…The core umami and bitter taste peptides were synthesized using an APEX 396 automated peptide synthesizer (AAPPTEC, USA) based on the conventional Fmoc solid-phase synthesis method. 27 The purity of the synthesised peptides was analyzed using HPLC (Shimadzu LCMS-2020, Japan) with a Sinochrom ODS-BP column (4.6 × 250 mm, 5 μm). Solvent A was 0.1% trifluoroacetic acid in 100% acetonitrile and solvent B was 0.1% trifluoroacetic acid in 100% water.…”

Section: Methodsmentioning

confidence: 99%

Comparison of the taste mechanisms of umami and bitter peptides from fermented mandarin fish (Chouguiyu) based on molecular docking and electronic tongue technology

Li,

Yang,

et al. 2023

Food Funct.

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Section: Methodsmentioning

confidence: 99%

Comparison of the taste mechanisms of umami and bitter peptides from fermented mandarin fish (Chouguiyu) based on molecular docking and electronic tongue technology

Li,

Yang,

et al. 2023

Food Funct.

Self Cite

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“…Screened peptides exhibit diverse physiological effects, such as suppressing the activity of some unfavorable enzymes in the human body (Yang et al, 2022;Zhao et al, 2023;Zhou, Safdar, et al, 2023). These studies mainly focused on treating diabetes (Yang et al, 2022), hypertension (Chen, Wang, et al, 2023), hyperuricemia (Zhao et al, 2023), and others. Molecular docking can be seen as a virtual screening of food ingredients with therapeutic effects.…”

Section: Mechanism Exploration Of Enzyme Activitymentioning

confidence: 99%

“…Screened peptides exhibit diverse physiological effects, such as suppressing the activity of some unfavorable enzymes in the human body (Yang et al., 2022; Zhao et al., 2023; Zhou, Safdar, et al., 2023). These studies mainly focused on treating diabetes (Yang et al., 2022), hypertension (Chen, Wang, et al., 2023), hyperuricemia (Zhao et al., 2023), and others. Molecular docking can be seen as a virtual screening of food ingredients with therapeutic effects.…”

Section: Applications Of Molecular Simulation To Food Protein–ligand ...mentioning

confidence: 99%

Molecular simulation for food protein–ligand interactions: A comprehensive review on principles, current applications, and emerging trends

Jin,

Wei

2023

Comp Rev Food Sci Food Safe

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In recent years, investigations on molecular interaction mechanisms between food proteins and ligands have attracted much interest. The interaction mechanisms can supply much useful information for many fields in the food industry, including nutrient delivery, food processing, auxiliary detection, and others. Molecular simulation has offered extraordinary insights into the interaction mechanisms. It can reflect binding conformation, interaction forces, binding affinity, key residues, and other information that physicochemical experiments cannot reveal in a fast and detailed manner. The simulation results have proven to be consistent with the results of physicochemical experiments. Molecular simulation holds great potential for future applications in the field of food protein–ligand interactions. This review elaborates on the principles of molecular docking and molecular dynamics simulation. Besides, their applications in food protein–ligand interactions are summarized. Furthermore, challenges, perspectives, and trends in molecular simulation of food protein–ligand interactions are proposed. Based on the results of molecular simulation, the mechanisms of interfacial behavior, enzyme‐substrate binding, and structural changes during food processing can be reflected, and strategies for hazardous substance detection and food flavor adjustment can be generated. Moreover, molecular simulation can accelerate food development and reduce animal experiments. However, there are still several challenges to applying molecular simulation to food protein–ligand interaction research. The future trends will be a combination of international cooperation and data sharing, quantum mechanics/molecular mechanics, advanced computational techniques, and machine learning, which contribute to promoting food protein–ligand interaction simulation. Overall, the use of molecular simulation to study food protein–ligand interactions has a promising prospect.

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Isolation and characterization of DPP-IV inhibitory peptide from rabbit meat hydrolysate: Mechanism, gastrointestinal resistance, and hypoglycemic effects of Leucyl-Leucine (LL)

Hu,

Li,

Chen

et al. 2024

Food Bioscience

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Discovery and functional mechanism of novel dipeptidyl peptidase Ⅳ inhibitory peptides from Chinese traditional fermented fish (Chouguiyu)

Cited by 7 publications

References 45 publications

Comparison of the taste mechanisms of umami and bitter peptides from fermented mandarin fish (Chouguiyu) based on molecular docking and electronic tongue technology

Comparison of the taste mechanisms of umami and bitter peptides from fermented mandarin fish (Chouguiyu) based on molecular docking and electronic tongue technology

Molecular simulation for food protein–ligand interactions: A comprehensive review on principles, current applications, and emerging trends

Isolation and characterization of DPP-IV inhibitory peptide from rabbit meat hydrolysate: Mechanism, gastrointestinal resistance, and hypoglycemic effects of Leucyl-Leucine (LL)

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