Discovery and structure–activity relationships of pyrazolodiazepine derivatives as the first small molecule agonists of the Drosophila sex peptide receptor

G protein coupled receptors as targets for next generation pesticides

“…The D. melanogaster and D. suzukii sex peptide receptors share very high sequence identity. Kim et al (2015) have screened a compound library based on a pyrazolodiazepine scaffold to discover small molecule agonists for the D. melanogaster sex peptide receptor. Structure-activity studies of the hit compounds resulted in the synthesis of two potent analogues.…”

Combinatorial Chemistry Online Volume 17, Issue 6, June 2015

“…To discover small molecule agonists for DrmSPR, a compound library based on a pyrazolodiazepine scaffold, previously reported as a potential privileged structure, was screened. Structure-activity relationship studies of the hit compounds, were explored through analog synthesis resulting in 6-benzyl pyrazolodiazepine derivatives found to be small molecule agonists for DrmSPR [16].…”