2020
DOI: 10.1097/cce.0000000000000195
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Discovery and Validation of Urinary Molecular Signature of Early Sepsis

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Cited by 9 publications
(22 citation statements)
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“…This is the first manuscript demonstrating targeted immunological profiles in the urine of patients with acute COVID-19 infection. It is also one of few studies demonstrating the utilization of urine as the source of immunological information 11 , 14 , 16 , 19 . The major value of the presented research is a demonstration that several immunological markers correlated with activation of the immune system, the severity of the disease, and clinical outcomes while using urine as the source material.…”
Section: Discussionmentioning
confidence: 99%
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“…This is the first manuscript demonstrating targeted immunological profiles in the urine of patients with acute COVID-19 infection. It is also one of few studies demonstrating the utilization of urine as the source of immunological information 11 , 14 , 16 , 19 . The major value of the presented research is a demonstration that several immunological markers correlated with activation of the immune system, the severity of the disease, and clinical outcomes while using urine as the source material.…”
Section: Discussionmentioning
confidence: 99%
“…However, predicting the inflammatory response is complex and often require intervention with blood collection, which is burdensome. Prior sepsis studies supported the use of urine samples as biomarkers for therapeutic and immunological monitoring 10 17 . Therefore, collecting urine samples for immune system monitoring may be an appealing alternative over blood sample collection, especially considering that many patients with COVID-19 infections receive treatment at home and blood draw can be challanging 18 , 19 .…”
Section: Introductionmentioning
confidence: 99%
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“… 5 The identification of altered molecular signatures and biochemical pathways in sepsis patients has driven interest in the discovery of novel biomarkers. 6 Early recognition of sepsis is essential for timely treatment and can improve sepsis outcomes. 7 , 8 Mortality risk is higher when sepsis treatment is delayed.…”
Section: Introductionmentioning
confidence: 99%