Discovery of 1-aryloxyethyl piperazine derivatives as Kv1.5 potassium channel inhibitors (part I)

Guo, Xiaoke; Ma, Xianglei; Yang, Qian; Xu, Junmei; Jia, Jianmin; Shan, Jiaojiao; Liu, Li; Chen, Weilin; Chu, Hongxi; Wei, Jinlian; Zhang, Xiaojin; Sun, Haopeng; Tang, Yiqun; You, Qidong

doi:10.1016/j.ejmech.2014.03.075

Cited by 16 publications

(12 citation statements)

References 29 publications

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“…Over the last years, sST2 has been considered as a very promising biomarker to diagnose or monitor patients with One-vessel disease, n (%) 57 (21) Two-vessel disease, n (%) 37 (14) Three-vessel disease, n (%) 52 (19) Myocardial infarction, n (%) 28 (10) Atrial fibrillation, n (%) 26 (9) Stroke, n (%) 10 (4) Peripheral artery disease, n (%) 77 (28) COPD, n (%) 64 (23) Transfemoral access, n (%) 212 (77) heart failure and was investigated as a biomarker in many large clinical trials, mainly in heart failure patients, but also in patients with myocardial infarction [26,28,29]. Moreover, sST2 Figure 1 After 1 year, patients with a sST2 concentration above the optimal cut-off of 10 070Á27 pg/mL evidenced a significantly worse outcome (49Á2% vs. 23Á2%; OR 3Á21 95% CI (1Á70-6Á04); P < 0Á001).…”

Section: Discussionmentioning

confidence: 99%

Soluble ST2 predicts 1‐year outcome in patients undergoing transcatheter aortic valve implantation

Wernly

Lichtenauer

Jirak

et al. 2017

Eur J Clin Investigation

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Section: Discussionmentioning

confidence: 99%

Soluble ST2 predicts 1‐year outcome in patients undergoing transcatheter aortic valve implantation

Wernly

Lichtenauer

Jirak

et al. 2017

Eur J Clin Investigation

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“…In the latter,t he inclusion of dispersion correction lowers the relative energy of the folded conformationb ut the repulsion between the phenyl groups still plays the dominant role. As imilar free-molecule structure for the same compound was already found by calculations and fluorescenced ip infrared spectroscopy (FDIR) by Buchanan et al [24] Synthesis For ap reparative access to the model compounds, we used a modified protocol by Guo et al [25] Scheme 2d isplays an exemplary route to the asymmetric compound 1-(pentafluorophenoxy)-2-(phenoxy)ethane (2).…”

Section: Resultsmentioning

confidence: 74%

Inter‐ and Intramolecular Aryl–Aryl Interactions in Partially Fluorinated Ethylenedioxy‐bridged Bisarenes**

Weddeling

Vishnevskiy

Neumann

et al. 2020

Chemistry A European J

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Several ethylenedioxy-bridged bisarenes with a variety of type and number of aryl groups were synthesized to study non-covalent dispersion-driven inter-and intramolecular aryl-aryl-interactions in the solid state and gas phase. Intramolecular interactions are preferably found in the gas phase. DFT calculations of dispersion-corrected energy scans for rotations around the ethylenedioxy-bridge and optimized structures show larger interacting aromatic groups to increase the dispersion energy. Single molecule structures generally adopt folded conformations with short intramolecular aryl-aryl-contacts. Gas electron diffraction experiments were performed exemplarily for 1-(pentafluorophenoxy)-2-(phenoxy)ethane. A new procedure for structure refinement was developed to deal with the conformational complexity of such molecules. The results are an experimental confirmation of the existence of folded conformations of this molecule with short-intramolecular aryl-aryl distances in the gas phase. Solid-state structures are dominated by stretched structures without intramolecular aryl-aryl-interactions but interactions with neighboring molecules.

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“…For the synthesis of the probe 2 , the fluorescein moiety 3 was treated with 1,2‐dibromo ethane in the presence of excess K 2 CO 3 at 60 °C to give compound 8 . The compound 8 was next subjected to nucleophilic substitution by NaN 3 to yield the corresponding bis ‐azido derivative 9 in 96 % crude yield.…”

Section: Methodsmentioning

confidence: 99%

Carbohydrates in Fluoride Sensing: Use of Cyclodextrin and CNC‐Based Chemical Probes

Das

Mukhopadhyay

2017

ChemistrySelect

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Despite significant development in the area, efficient sensing of fluoride ions in aqueous media remained a serious challenge. In this communication we report the design and synthesis of two eco‐friendly carbohydrate‐based probes for the fluorimetric sensing of fluoride ions. The novel probes are fully characterized with NMR, UV‐Vis, FTIR and MALDI‐TOF. The probes showed selective detection of fluoride anion within the permissible limit set by WHO. The organic cellulose nanocomposite (CNC) based probe showed the lowest detection limit among other carbohydrate‐based probes for the detection of fluoride anion. In addition to the excellent sensitivity, these probes are particularly attractive for their bio‐availability and non‐toxic nature.

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Discovery of 1-aryloxyethyl piperazine derivatives as Kv1.5 potassium channel inhibitors (part I)

Cited by 16 publications

References 29 publications

Soluble ST2 predicts 1‐year outcome in patients undergoing transcatheter aortic valve implantation

Soluble ST2 predicts 1‐year outcome in patients undergoing transcatheter aortic valve implantation

Inter‐ and Intramolecular Aryl–Aryl Interactions in Partially Fluorinated Ethylenedioxy‐bridged Bisarenes**

Carbohydrates in Fluoride Sensing: Use of Cyclodextrin and CNC‐Based Chemical Probes

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