Discovery of 6‐Acylamino/Sulfonamido Benzoxazolone with IL‐6 Inhibitory Activity as Promising Therapeutic Agents for Ulcerative Colitis
Rui Ge,
Jiaqi Song,
Zhen Cao
et al.
Abstract:Ulcerative colitis has been widely concerned for its persistent upward trend and sustained overproduction of pro‐inflammatory cytokines such as IL‐6 remains a crucial factor in UC development. Therefore, identification of new effective drugs to block inflammatory responses is an urgent and viable strategy for UC. In our research, twenty‐three 6‐acylamino/sulfonamido benzoxazolone derivatives were synthesized, characterized, and evaluated for anti‐inflammatory activity against NO and IL‐6 in LPS‐induced RAW264.… Show more
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