Discovery of a novel DNA binding agent via design and synthesis of new thiazole hybrids and fused 1,2,4-triazines as potential antitumor agents: Computational, spectrometric and in silico studies

Anticancer activity of pyrimidodiazepines based on 2-chloro-4-anilinoquinazoline: synthesis, DNA binding and molecular docking

“…The NCI COMPARE algorithm (https://dtp.cancer.gov/ databases_tools/compare.htm) indicates a correlation between compounds with known biological targets, which have been used extensively to predict and identify the mechanisms of action of synthetic and natural products. [32][33][34] Therefore, the in vitro antitumor screening of compounds 14g, 16a and 16c were analyzed using COMPARE algorithm against the NCI standard drugs database at the GI 50 and LC 50 levels. The algorithm ranks the results of the tested compound in order of the similarity of responses against 60 human tumor cell lines, 31 expressed quantitatively as Pearson correlation coefficient (PCC) as shown in Table 3.…”

Effect of a novel thiazole derivative and its complex with a polymeric carrier on stability of DNA in human breast cancer cells

“…The thiazole-based compounds were created for targeting pathological cells, including tumor cells [5][6][7][8][9][10][11][12]. However, these compounds are often not easy to use because they are not soluble in water and the mechanisms of their action are not known.…”

“…These findings correlate with previously reported data that 2-amino-5-benzylthiazole derivatives (2,8-dimethyl-7-(3-trifluoromethyl-benzyl)pyrazolo [4,3-e]thiazolo [3,2-a]pyrimidin-4(2H)one; and 7-benzyl-8-methyl-2-propylpyrazolo [4,3-e] thiazolo [3,2-a]pyrimidin-4(2H)-one) induced DNA single-strand breaks and DNA fragmentation in human leukemia cells without significant DNA binding and DNA intercalation [25]. The furan-thiazole hybrid (compound 3d) exhibited its anticancer activity via DNA binding and DNA damage [12].…”

“…The thiazole derivatives are characterized by a wide range of biological activities (anticancer, antibacterial, antifungal, antiviral, anti-inflammatory, neuroprotective) [1,[5][6][7][8][9][10][11]. Anticancer activity was reported for tiazofurin, dasatinib, and a furan-thiazole hybrid [11,12].…”

Bicyclic 5-6 Systems With One Bridgehead (Ring Junction) Nitrogen Atom: Four Extra Heteroatoms 2:2

“…[55][56] Finally, S-alkylation of the thiocarbonyl group of thiadiazole-thione 158 has been performed in DMF with potassium hydroxide to produce various thioalkyl derivatives 159 (Scheme 25). 57…”