Discovery of a Novel Hepatovirus (
            <i>Phopivirus</i>
            of Seals) Related to Human Hepatitis A Virus

Anthony, Simon J.; Leger, J. A. St.; Liang, Eliza; Hicks, Alan C.; Sanchez-Leon, M. D.; Jain, Komal; Lefkowitch, Jay H.; Navarrete-Macias, Isamara; Knowles, Nick J.; Goldstein, Tracey; Pugliares, Katie R.; Ip, Hon S.; Rowles, Teri; Lipkin, W. Ian

doi:10.1128/mbio.01180-15

Cited by 48 publications

(54 citation statements)

References 33 publications

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“…Although these results are of importance, mammals and birds represent only a small proportion (less than 25%) of total number of vertebrates, and little is known about the natural viromes of the vast number of vertebrate species. Indeed, recent metagenomic studies [6][7][8][9][10][11] suggest that our understanding of the true biodiversity and evolution of vertebrate RNA viruses is limited, fragmentary and biased.…”

Section: Introductionmentioning

confidence: 99%

The diversity, evolution and origins of vertebrate RNA viruses

Zhang

Shī

et al. 2018

Current Opinion in Virology

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Despite a substantial increase in our knowledge of the biodiversity and evolution of vertebrate RNA viruses, far less is known about the diversity, evolution and origin of RNA viruses across the diverse phylogenetic range of viruses, and particularly in healthy animals that are often only rarely utilized for virological sampling. Fortunately, recent advances in virus discovery using metagenomic approaches are beginning to reveal a multitude of RNA viruses in vertebrates other than birds and mammals. In particular, fish harbor a remarkable array of RNA viruses, including the relatives of important pathogens. In addition, despite frequent cross-species transmission, the RNA viruses in vertebrates generally follow the evolutionary history of their hosts, which began in the oceans and then moved to terrestrial habitats over timescales covering hundreds of millions of years.

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Section: Introductionmentioning

confidence: 99%

The diversity, evolution and origins of vertebrate RNA viruses

Zhang

Shī

et al. 2018

Current Opinion in Virology

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“…23,24 A plethora of HAV-related viruses were recovered from various mammalian species during 2015-2018, including predominantly bats and rodents, but also tree shrews, seals and marsupials. [25][26][27][28][29] HBV-related viruses were detected in bats during 2013-2015 30,31 and in a domestic cat in 2018. 32 A distinct HBV species termed capuchin monkey hepatitis B virus (CMHBV) was described in 2018.…”

Section: A New Era Of Virus Discoverymentioning

confidence: 99%

Evolutionary biology of human hepatitis viruses

Rasche

Sander

Corman

et al. 2019

Journal of Hepatology

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“…However, this "prejudice" has already been challenged and overturned by animal model engineering as well as by new scientific discoveries. In 2015, several strains of human HAV have been found in seals, which may indicate that the first natural nonprimate HAV to be discovered, and provide further understanding for the evolutionary history and pathogenicity of HAV [98]. Moreover, in recent years, HAV-associated hepatoviruses have been found in bats, rodents, hedgehogs [38], duck [99][100][101], and woodchucks [102,103], which suggested that there may be more candidate animals potentially used as animal models of HAV.…”

Section: Other Animal Modelsmentioning

confidence: 99%

Applications of Animal Models in Researching Hepatitis A

Lin¹,

Min²,

Li³

et al. 2020

Hepatitis a and Other Associated Hepatobiliary Diseases

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Hepatitis diseases are remaining in the list of significant threats to human health. Human hepatitis viruses are basically classified into six major hepatotropic pathogens-hepatitis A virus (HAV), hepatitis B virus (HBV), hepatitis C virus (HCV), hepatitis D virus (HDV), hepatitis E virus (HEV), and hepatitis G virus (HGV). Among these different forms of hepatotropic viruses, HAV as the leading cause of acute viral hepatitis is characterized as a kind of tiny ribonucleic acid virus that is linked to atopic disease. As we know, animal models have been instrumental in promoting understanding of complex host-virus interactions and boosting the advancement of immune therapies. So far, animal models such as nonhuman primates (NHPs) have enabled scientists to mimic and study the pathogenicities and host immune responses for hepatitis A infection. With the exception of chimpanzees and marmosets, animals like mice, pigs, guinea pigs, and tree shrews can also be selected as alternative animal models infected with HAV under laboratory conditions. In order to gain a better insight into hepatitis A pathogenesis and relevant contents, this chapter is mainly focused on the research progress in animal models of hepatitis A, and discusses the merits and demerits of these alternative models.

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Discovery of a Novel Hepatovirus ( Phopivirus of Seals) Related to Human Hepatitis A Virus

Cited by 48 publications

References 33 publications

The diversity, evolution and origins of vertebrate RNA viruses

The diversity, evolution and origins of vertebrate RNA viruses

Evolutionary biology of human hepatitis viruses

Applications of Animal Models in Researching Hepatitis A

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