Discovery of a novel nitroimidazolyl–oxazolidinone hybrid with potent anti Gram-positive activity: Synthesis and antibacterial evaluation

Design, Synthesis and Antibacterial Evaluation of Some New 2-Phenyl-quinoline-4-carboxylic Acid Derivatives

“…On the other hand, alterations of the basic terminus of the amide side chains at the ortho-position of the 2-phenyl group led to varying effects on antibacterial activity. Compounds 5a 4 , 5a 3 , 5a 2 and 5b 4 showed better antibacterial activity than Compounds 5a 6 , 5a 7 and 5b 6 against S. aureus and B. subtilis, indicating that rigid cyclic amino group at 2-phenyl is suitable for the anti-Gram-positive bacteria activity. On the contrary, for E. coli, Compounds 5a 6 , 5a 7 and 5b 6 exhibited stronger activity than the compounds with rigid cyclic amino substituents(5a 2 , 5a 3 , 5a 4 , 5b 4 ), suggesting that the flexible chain amino group at 2-phenyl can enhance antibacterial activity against E. coli.…”

“…Furthermore, many drug-resistant pathogens have emerged in recent years because of the increasing use or abuse of antibacterial agents [2,3], and antibiotic drug resistance has become a growing problem across the globe in recent years [4]. Currently, many advances for combating antimicrobial resistance have been achieved, such as modifications/improvements of existing antibiotic classes, some anti-adhesion agents against Gram-positive pathogens [5] and efflux pump inhibitors (EPIs) [6].…”

One-pot regioselective synthesis of new 5-(arylsulfonylamino)imidazo[2,1-b]thiazoles

“…For example, imidazo [2,1-b]thiazoles are inhibitors of acetylcholine esterase 15 and other enzymes, 16,17 as well as receptor inhibitors. 18 They also demonstrate diuretic, 19 antitumour, [20][21][22][23] antimicrobial, 24,25 fungicidal 26 and antihelmintic 27 activity. The most efficient method to obtain imidazo [2,1-b]thiazoles is the conversion of 2-aminothiazole with α-halocarbonyl compounds or propargylbromide (Scheme 2).…”

Synthesis and antimicrobial activity of 1,3-bis-butyl-5-(4-iodophenyl)-1,3,5-triazacyclohexane

“…Antibiotic resistance is a major problem in hospitals as well as in community settings [9]. Considering the ever growing antibiotic resistance developed by many bacteria, there is an immense need for new compounds with new mode of actions, for treatment of bacterial infections [10].…”