Discovery of a novel series of α-terpineol derivatives as promising anti-asthmatic agents: Their design, synthesis, and biological evaluation

Zhu, Wanpeng; Liu, Xia; Wang, Yuji; Tong, Yeling; Hu, Yongzhou

doi:10.1016/j.ejmech.2017.07.068

Cited by 19 publications

(15 citation statements)

References 13 publications

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“…It has anti‐inflammatory and analgesic actions, antioxidant properties,anti‐proliferative and anti‐cancer effects especially in small cell lung carcinoma, antibacterial, antifungal, and antiviral effects. It also has skin penetration enhancing effects, airway smooth muscle relaxation in asthma, vasorelaxation and blood pressure reduction effects, and anxiolytic and sedative effects …”

Section: Terpenes (Terpenoids)mentioning

confidence: 99%

Medicinal Properties of Cannabinoids, Terpenes, and Flavonoids in Cannabis, and Benefits in Migraine, Headache, and Pain: An Update on Current Evidence and Cannabis Science

2018

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There is accumulating evidence for various therapeutic benefits of cannabis/cannabinoids, especially in the treatment of pain, which may also apply to the treatment of migraine and headache. There is also supporting evidence that cannabis may assist in opioid detoxification and weaning, thus making it a potential weapon in battling the opioid epidemic. Cannabis science is a rapidly evolving medical sector and industry with increasingly regulated production standards. Further research is anticipated to optimize breeding of strain-specific synergistic ratios of cannabinoids, terpenes, and other phytochemicals for predictable user effects, characteristics, and improved symptom and disease-targeted therapies.

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Section: Terpenes (Terpenoids)mentioning

confidence: 99%

Medicinal Properties of Cannabinoids, Terpenes, and Flavonoids in Cannabis, and Benefits in Migraine, Headache, and Pain: An Update on Current Evidence and Cannabis Science

2018

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“…Dasgupta et al (2019) compound; and catalytic hydrogenation) in order to pursue more favorable biological properties, such as improved bioavailability and prolonged elimination half-life. Of these, eight derivatives showed enhanced airway smooth muscle relaxation activity (Zhu et al 2018).…”

Section: Bicas Et Al (2011)mentioning

confidence: 99%

Production, Properties, and Applications of α-Terpineol

Sales

Felipe

Bicas

2020

Food Bioprocess Technol

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α-Terpineol (CAS No. 98-55-5) is a tertiary monoterpenoid alcohol widely and commonly used in the flavors and fragrances industry for its sensory properties. It is present in different natural sources, but its production is mostly based on chemical hydration using α-pinene or turpentine. Moreover, many bioprocesses for the microbial production of α-terpineol via biotransformation of monoterpenes (limonene, αand β-pinenes) are also available in the literature. In addition to its traditional use, αterpineol has also been evaluated in other application fields (e.g., medical), since some biological properties other than aroma, such as antioxidant, anti-inflammatory, antiproliferative, antimicrobial, and analgesic effects, among others, have been attributed to this compound. Therefore, this review presents an original compilation of data regarding the production (extraction directly from nature; chemical synthesis; via biotechnological process), the chemical and biological properties, and the current market and novel applications of α-terpineol to guide further research in this area. Considering the information presented, we believe that αterpineol applications may transcend the flavors and fragrances industry in the future.

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“…In the mouse asthma model, inhalation of limonene significantly reduced the levels of various proinflammation-related molecules as well as airway fibrosis, indicating that limonene has the potential to reduce airway remodeling [158]. Further in vivo investigation using an asthmatic rat model, a novel series of α-terpineol derivatives improved lung function as well as enhanced airway smooth muscle relaxation activity [17]. In addition, borneol and terpineol, extracted from a traditional Chinese formulation for the treatment of asthma, inhibited histamine-induced in vitro bronchoconstriction of isolated tracheal smooth muscles in guinea pigs, thus, indicating anti-asthmatic action [159].…”

Section: Respiratory Inflammationmentioning

confidence: 96%

“…Among them, the beneficial effects of terpene and terpenoid compounds on human health have been attracting the attention of numerous researchers, and their roles in various human disease processes, such as inflammatory diseases, tumorigenesis, and neurodegeneration, have been studied using cell and animal models for many decades, suggesting terpenes and terpenoids as potential chemopreventive and therapeutic agents for various diseases [14][15][16]. In recent years, small subgroups of novel terpenes and terpenoids have been isolated or synthesized, providing more potentially chemotherapeutic terpene compounds for clinical trials [17].…”

Section: Terpenes and Terpenoidsmentioning

confidence: 99%

Therapeutic Potential of Volatile Terpenes and Terpenoids from Forests for Inflammatory Diseases

Kim

Song

Cho

et al. 2020

IJMS

176

131

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Forest trees are a major source of biogenic volatile organic compounds (BVOCs). Terpenes and terpenoids are known as the main BVOCs of forest aerosols. These compounds have been shown to display a broad range of biological activities in various human disease models, thus implying that forest aerosols containing these compounds may be related to beneficial effects of forest bathing. In this review, we surveyed studies analyzing BVOCs and selected the most abundant 23 terpenes and terpenoids emitted in forested areas of the Northern Hemisphere, which were reported to display anti-inflammatory activities. We categorized anti-inflammatory processes related to the functions of these compounds into six groups and summarized their molecular mechanisms of action. Finally, among the major 23 compounds, we examined the therapeutic potentials of 12 compounds known to be effective against respiratory inflammation, atopic dermatitis, arthritis, and neuroinflammation among various inflammatory diseases. In conclusion, the updated studies support the beneficial effects of forest aerosols and propose their potential use as chemopreventive and therapeutic agents for treating various inflammatory diseases.

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Discovery of a novel series of α-terpineol derivatives as promising anti-asthmatic agents: Their design, synthesis, and biological evaluation

Cited by 19 publications

References 13 publications

Medicinal Properties of Cannabinoids, Terpenes, and Flavonoids in Cannabis, and Benefits in Migraine, Headache, and Pain: An Update on Current Evidence and Cannabis Science

Medicinal Properties of Cannabinoids, Terpenes, and Flavonoids in Cannabis, and Benefits in Migraine, Headache, and Pain: An Update on Current Evidence and Cannabis Science

Production, Properties, and Applications of α-Terpineol

Therapeutic Potential of Volatile Terpenes and Terpenoids from Forests for Inflammatory Diseases

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